Dipropyltryptamine
Encyclopedia
Dipropyltryptamine is a psychedelic
drug
belonging to the tryptamine
family, first reported in 1973. It is found either as its crystalline hydrochloride
salt
or as an oily or crystalline base
. It has not been found to occur naturally.
Frequent physical effects are nausea
, numbness
of the tongue
or throat
, and pupil dilation
.
antagonist
blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor
antagonist also imply a 5-HT1A-mediated component to the actions of DPT.
, its psychoactive effects are markedly different.
The most prominent features of the DPT experience are increased significance or intensity of music
, color
s take on a new intensity or appearance, the body may have a buzz or vibratory feeling, a pleasant sensation of warmth, complete ego loss, apparitions
of faces.
While seeing other beings under the influence of DPT may occasionally occur, the perspective is more as an observer or watcher, as contrasted to the more personal real-feeling entity contact reported with DMT
.
Also sometimes reported is a loss of ego boundary; for example, the boundary between the self
and a table
may not be easy to distinguish. Difficulty distinguishing other boundaries is common as well. For example, different colors may be difficult to distinguish. Other sensory input may also become blended. This is distinct from synaesthesia.
A user may also encounter the feeling of experiencing the life of someone else, or having had all possible experiences simultaneously. One may have the experience of seeing the universe
from different locations in space
and time
.
Visuals are often geometric, wavy, and/or spiraled. Other visual distortions and hallucinations tend to be experienced in the peripheral vision. The self or the environment may take on a stylized cartoon
-like look or feel. Pleasant flashes of light and sparkles are also common.
Smoked: When smoked
, the effects of DPT have an onset in minutes and a duration of less than one hour. Dosage ranges from 30-100 mg.
Insufflation: Average onset for insufflation
of DPT is five to fifteen minutes, and typical dosage ranges from 45–225 mg.
Intramuscular: When injected
into the muscle
, onset ranges from one minute to fifteen minutes. Typical dosage ranges from 20–110 mg.
Intravenous: When injected intravenously
, onset ranges from five to fifteen seconds. Typical dosage ranges from 10–75 mg.
Oral Ingestion: DPT is metabolized
by the enzyme
monoamine oxidase
. While DPT is orally active on its own, the combination with a monoamine oxidase inhibitor
(MAOI) can increase the length and intensity of the experience. Oral dosages of 150 – 250 mg are commonly reported, with an onset of 20–60 minutes (depending on stomach content).
Psychedelics, dissociatives and deliriants
This general group of pharmacological agents can be divided into three broad categories: psychedelics, dissociatives, and deliriants. These classes of psychoactive drugs have in common that they can cause subjective changes in perception, thought, emotion and consciousness...
drug
Psychoactive drug
A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that crosses the blood–brain barrier and acts primarily upon the central nervous system where it affects brain function, resulting in changes in perception, mood, consciousness, cognition, and behavior...
belonging to the tryptamine
Tryptamine
Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived...
family, first reported in 1973. It is found either as its crystalline hydrochloride
Hydrochloride
In chemistry, hydrochlorides are salts resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base . This is also known as muriate, derived from hydrochloric acid's other name: muriatic acid....
salt
Salt
In chemistry, salts are ionic compounds that result from the neutralization reaction of an acid and a base. They are composed of cations and anions so that the product is electrically neutral...
or as an oily or crystalline base
Base (chemistry)
For the term in genetics, see base A base in chemistry is a substance that can accept hydrogen ions or more generally, donate electron pairs. A soluble base is referred to as an alkali if it contains and releases hydroxide ions quantitatively...
. It has not been found to occur naturally.
Frequent physical effects are nausea
Nausea
Nausea , is a sensation of unease and discomfort in the upper stomach with an involuntary urge to vomit. It often, but not always, precedes vomiting...
, numbness
Paresthesia
Paresthesia , spelled "paraesthesia" in British English, is a sensation of tingling, burning, pricking, or numbness of a person's skin with no apparent long-term physical effect. It is more generally known as the feeling of "pins and needles" or of a limb "falling asleep"...
of the tongue
Tongue
The tongue is a muscular hydrostat on the floors of the mouths of most vertebrates which manipulates food for mastication. It is the primary organ of taste , as much of the upper surface of the tongue is covered in papillae and taste buds. It is sensitive and kept moist by saliva, and is richly...
or throat
Throat
In vertebrate anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx...
, and pupil dilation
Mydriasis
Mydriasis is a dilation of the pupil due to disease, trauma or the use of drugs. Normally, the pupil dilates in the dark and constricts in the light to respectively improve vividity at night and to protect the retina from sunlight damage during the day...
.
Pharmacology
Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor . This is the main excitatory receptor subtype among the GPCRs for serotonin , although 5-HT2A may also have an inhibitory effect on certain areas such...
antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor
5-HT1A receptor
The 5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin . It is a G protein-coupled receptor that is coupled to Gi/Go and mediates inhibitory neurotransmission...
antagonist also imply a 5-HT1A-mediated component to the actions of DPT.
Psychedelic properties
While dipropyltryptamine is chemically similar to dimethyltryptamineDimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...
, its psychoactive effects are markedly different.
The most prominent features of the DPT experience are increased significance or intensity of music
Music
Music is an art form whose medium is sound and silence. Its common elements are pitch , rhythm , dynamics, and the sonic qualities of timbre and texture...
, color
Color
Color or colour is the visual perceptual property corresponding in humans to the categories called red, green, blue and others. Color derives from the spectrum of light interacting in the eye with the spectral sensitivities of the light receptors...
s take on a new intensity or appearance, the body may have a buzz or vibratory feeling, a pleasant sensation of warmth, complete ego loss, apparitions
Apparitional experience
In psychology and parapsychology, an apparitional experience is an anomalous, quasi-perceptual experience.It is characterized by the apparent perception of either a living being or an inanimate object without there being any material stimulus for such a perception...
of faces.
While seeing other beings under the influence of DPT may occasionally occur, the perspective is more as an observer or watcher, as contrasted to the more personal real-feeling entity contact reported with DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...
.
Also sometimes reported is a loss of ego boundary; for example, the boundary between the self
Self
The self is an individual person as the object of his or her own reflective consciousness. The self has been studied extensively by philosophers and psychologists and is central to many world religions.-Philosophy:...
and a table
Table (furniture)
A table is a form of furniture with a flat and satisfactory horizontal upper surface used to support objects of interest, for storage, show, and/or manipulation...
may not be easy to distinguish. Difficulty distinguishing other boundaries is common as well. For example, different colors may be difficult to distinguish. Other sensory input may also become blended. This is distinct from synaesthesia.
A user may also encounter the feeling of experiencing the life of someone else, or having had all possible experiences simultaneously. One may have the experience of seeing the universe
Universe
The Universe is commonly defined as the totality of everything that exists, including all matter and energy, the planets, stars, galaxies, and the contents of intergalactic space. Definitions and usage vary and similar terms include the cosmos, the world and nature...
from different locations in space
Space
Space is the boundless, three-dimensional extent in which objects and events occur and have relative position and direction. Physical space is often conceived in three linear dimensions, although modern physicists usually consider it, with time, to be part of a boundless four-dimensional continuum...
and time
Time
Time is a part of the measuring system used to sequence events, to compare the durations of events and the intervals between them, and to quantify rates of change such as the motions of objects....
.
Visuals are often geometric, wavy, and/or spiraled. Other visual distortions and hallucinations tend to be experienced in the peripheral vision. The self or the environment may take on a stylized cartoon
Cartoon
A cartoon is a form of two-dimensional illustrated visual art. While the specific definition has changed over time, modern usage refers to a typically non-realistic or semi-realistic drawing or painting intended for satire, caricature, or humor, or to the artistic style of such works...
-like look or feel. Pleasant flashes of light and sparkles are also common.
Dose
Note: These dosages should not be used as a guide for administrating the drug as individual gene polymorphism can cause great variance in effects from the same dose from one person to the next.Smoked: When smoked
Smoking
Smoking is a practice in which a substance, most commonly tobacco or cannabis, is burned and the smoke is tasted or inhaled. This is primarily practised as a route of administration for recreational drug use, as combustion releases the active substances in drugs such as nicotine and makes them...
, the effects of DPT have an onset in minutes and a duration of less than one hour. Dosage ranges from 30-100 mg.
Insufflation: Average onset for insufflation
Insufflation (medicine)
Insufflation is the practice of inhaling a substance. Insufflation has limited medical use, but is a common route of administration with many respiratory drugs used to treat conditions in the lungs and paranasal sinus .The technique is common for many recreational drugs and is also used for some...
of DPT is five to fifteen minutes, and typical dosage ranges from 45–225 mg.
Intramuscular: When injected
Injection (medicine)
An injection is an infusion method of putting fluid into the body, usually with a hollow needle and a syringe which is pierced through the skin to a sufficient depth for the material to be forced into the body...
into the muscle
Muscle
Muscle is a contractile tissue of animals and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They are classified as skeletal, cardiac, or smooth muscles. Their function is to...
, onset ranges from one minute to fifteen minutes. Typical dosage ranges from 20–110 mg.
Intravenous: When injected intravenously
Intravenous therapy
Intravenous therapy or IV therapy is the infusion of liquid substances directly into a vein. The word intravenous simply means "within a vein". Therapies administered intravenously are often called specialty pharmaceuticals...
, onset ranges from five to fifteen seconds. Typical dosage ranges from 10–75 mg.
Oral Ingestion: DPT is metabolized
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
by the enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
monoamine oxidase
Monoamine oxidase
L-Monoamine oxidases are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was originally discovered by Mary Bernheim in the liver and was named tyramine oxidase...
. While DPT is orally active on its own, the combination with a monoamine oxidase inhibitor
Monoamine oxidase inhibitor
Monoamine oxidase inhibitors are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating atypical depression....
(MAOI) can increase the length and intensity of the experience. Oral dosages of 150 – 250 mg are commonly reported, with an onset of 20–60 minutes (depending on stomach content).