Glycoside hydrolase family 1
Encyclopedia
Glycoside hydrolase family 1 is a family
Protein family
A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....

 of glycoside hydrolases
Glycoside hydrolase
Glycoside hydrolases catalyze the hydrolysis of the glycosidic linkage to release smaller sugars...

.

Glycoside hydrolases  are a widespread group of enzymes that hydrolyse the glycosidic bond
Glycosidic bond
In chemistry, a glycosidic bond is a type of covalent bond that joins a carbohydrate molecule to another group, which may or may not be another carbohydrate....

 between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Glycoside hydrolase family 1 CAZY GH_1 comprises enzymes with a number of known activities; beta-glucosidase ; beta-galactosidase
Beta-galactosidase
β-galactosidase, also called beta-gal or β-gal, is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins...

 ; 6-phospho-beta-galactosidase
6-phospho-beta-galactosidase
In enzymology, a 6-phospho-beta-galactosidase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are 6-phospho-beta-D-galactoside and H2O, whereas its two products are 6-phospho-D-galactose and alcohol....

 ; 6-phospho-beta-glucosidase
6-phospho-beta-glucosidase
In enzymology, a 6-phospho-beta-glucosidase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are 6-phospho-beta-D-glucosyl--D-glucose and H2O, whereas its two products are D-glucose and D-glucose 6-phosphate....

 ; lactase-phlorizin hydrolase , lactase
Lactase
Lactase , a part of the β-galactosidase family of enzymes, is a glycoside hydrolase involved in the hydrolysis of the disaccharide lactose into constituent galactose and glucose monomers...

 ; beta-mannosidase ; myrosinase
Myrosinase
Myrosinase is a family of enzymes involved in plant defense against herbivores. Their structure has been elucidated and is available.-Myrosinase activity:...

 .

Human proteins containing this domain

GBA3
GBA3
Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase enzyme that in humans is encoded by the GBA3 gene.- Function :...

; KL; KLB; LCT
Lactase
Lactase , a part of the β-galactosidase family of enzymes, is a glycoside hydrolase involved in the hydrolysis of the disaccharide lactose into constituent galactose and glucose monomers...

; LCTL;
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