HLA-DR2 of the HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

 system, is a broad antigen serotype that is now preferentially covered by HLA-DR15

HLA-DR15

HLA-DR15 is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies...

 and HLA-DR16

HLA-DR16

HLA-DR16 is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies...

 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles

DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
1501	76	23		6428
1502	77	16		676
1503	81	13		286
1504	>50			1
1505	>25			2
1507	>50			1
				.
	DR16	DR2	DR15	N
1601	41	29	19	703
1602	47	30	16	239
1604	>50			1

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, multiple sclerosis

Multiple sclerosis

Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

, and narcolepsy

Narcolepsy

Narcolepsy is a chronic sleep disorder, or dyssomnia, characterized by excessive sleepiness and sleep attacks at inappropriate times, such as while at work. People with narcolepsy often experience disturbed nocturnal sleep and an abnormal daytime sleep pattern, which often is confused with insomnia...

, tuberculoid leprosy (multi-drug resistant tuberculosis or leprosy), Hashimoto's thyroiditis

Hashimoto's thyroiditis

Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease in which the thyroid gland is gradually destroyed by a variety of cell- and antibody-mediated immune processes. It was the first disease to be recognized as an autoimmune disease...

, ulcerative colitis(Japanese), primary biliary cirrhosis

Primary biliary cirrhosis

Primary biliary cirrhosis, often abbreviated PBC, is an autoimmune disease of the liver marked by the slow progressive destruction of the small bile ducts within the liver. When these ducts are damaged, bile builds up in the liver and over time damages the tissue. This can lead to scarring,...

 and autoimmune hepatitis. DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetaes and chronic interstitial lung disease.