Haplotypes groups	DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1501
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1502
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1503
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1504
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1505
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1507
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR15 (DR15) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR15 is part of the older HLA-DR2

HLA-DR2

HLA-DR2 of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group...

 serotype group which also contains the similar HLA-DR16

HLA-DR16

HLA-DR16 is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies...

 antigens.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles

DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
1501	76	23		6428
1502	77	16		676
1503	81	13		286
1504	>50			1
1505	>25			2
1507	>50			1

Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522.
DRB1*1517N is a null.

Disease associations

DR15 is positively associated goodpasture syndrome, early age onset multiple sclerosis

Multiple sclerosis

Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

, pernicious anaemia, sarcoidosis, hypocretin deficiency associated narcolepsy
and a predisposition for postmenopausal osteoporosis.

DRB1*1501 is positively associated with Goodpasture syndrome, juvenile rheumatoid arthritis, allergic bronchopulmonary aspergillosis, multiple sclerosis

Multiple sclerosis

Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

, systemic lupus erythematosus

Systemic lupus erythematosus

Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...

, cervical cancer (human papillomavirus infection), and Sjogren's syndrome

Sjögren's syndrome

Sjögren's syndrome , also known as "Mikulicz disease" and "Sicca syndrome", is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands that produce tears and saliva....

 associated with systemic lupus erythematosus

Systemic lupus erythematosus

Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...

.

DRB1*1502 is associated with systemic lupus erythematosus

Systemic lupus erythematosus

Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...

, systemic sclerosis (SSc) & anti-topoisomerase antibodies

Anti-topoisomerase antibodies

Anti-topoisomerase antibodies are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins...

.

DRB1*1503 is associated with Chaga's cardiomyopathy, allergic bronchopulmonary aspergillosis, multiple sclerosis

Multiple sclerosis

Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

, cervical cancer

Cervical cancer

Cervical cancer is malignant neoplasm of the cervix uteri or cervical area. One of the most common symptoms is abnormal vaginal bleeding, but in some cases there may be no obvious symptoms until the cancer is in its advanced stages...

 (human papillomavirus

Human papillomavirus

Human papillomavirus is a member of the papillomavirus family of viruses that is capable of infecting humans. Like all papillomaviruses, HPVs establish productive infections only in keratinocytes of the skin or mucous membranes...

 infection).

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus

Systemic lupus erythematosus

Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...

Genetic Linkage

Serotypes	DRA	DRB1	| DRB5
DR15(2)-DR51	*0101	*1501	*0101
	*0101	*1502	*0101
	*0101	*1503	*0101
	*0101	*1504	*0101
	*0101	*1505	*0101
	*0101	*1507	*0101
	DQA1	DQB1	| DRB1
DR15(2)-DQ6(6.2, 1)	*0102	*0602	*1501
DR15(2)-DQ6(6.1, 1)	*0103	*0601	*1502
	HLA-A	HLA-B	DRB1
A3-Cw7-B7-DR15(2)	*0301	*0702	*1501
A1-B51-DR15(2)	*0101	*5101	*1502

HLA-DR15 is genetically linked to HLA-DR51

HLA-DR51

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...

 and HLA-DQ6

HLA-DQ6

HLA-DQ6 is a human leukocyte antigen serotype within HLA-DQ  serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently...

 (HLA-DQ1

HLA-DQ1

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 , DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in...

) serotypes.