Haplotypes groups	DRA*01:DRB1*1601 DRA*01:DRB1*1602
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1601
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1602
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1604
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR16(DR16) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2

HLA-DR2

HLA-DR2 of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group...

 serotype group which also contains the similar HLA-DR15

HLA-DR15

HLA-DR15 is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies...

 antigens.

Alleles

DR16, DR2 and other serotype recognition of some DRB1*16 alleles

DRB1*	DR16	DR2	DR15	Sample
allele	%	%	%	size (N)
1601	41	29	19	703
1602	47	30	16	239
1604	>50			1

Disease associations

DR16 is associated with Chaga's cardiomyopathy

Cardiomyopathy

Cardiomyopathy, which literally means "heart muscle disease," is the deterioration of the function of the myocardium for any reason. People with cardiomyopathy are often at risk of arrhythmia or sudden cardiac death or both. Cardiomyopathy can often go undetected, making it especially dangerous to...

, rheumatic heart disease, coronary artery ectasia, and chronic discoid lupus erythematosus.

DRB1*1601 is associated with tuberculosis

Tuberculosis

Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...

 risk

DRB1*1602: Juvenile rheumatoid arthritis

Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...

, rheumatic heart disease, Takayasu arteritis, systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody , melioidosis (Burkholderia pseudomallei infection)

Extended linkage

DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk

• • *1602:DQA1*0102:DQB1*0502 haplotype: graves disease, cervical caner (human papilloma virus infection), scleroderma
  • *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease, systemic sclerosis

Genetic Linkage

Serotypes	DRA	DRB1	| DRB5
DR16(2)-DR51	*0101	*1601	| *0101
	*0101	*1602	*0101
	*0101	*1604	*0101
	DQA1	DQB1	DRB1
DR16(2)-DQ5 (5.2, 1)	*0102	*0502	*1601
	HLA-A	HLA-B	DRB1
A2-B51(5)-DR16(2)	*0201	*5101	*1601

HLA-DR16 is genetically linked to HLA-DR51

HLA-DR51

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...

 and HLA-DQ5

HLA-DQ5

HLA-DQ4 is a human leukocyte antigen serotype subgroup within HLA-DQ serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4...

serotypes.