Haplotypes groups	DRA*01:DRB5*01 DRA*01:DRB5*02
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB5
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB5*01
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB5*02
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5

HLA-DRB5

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.- Function :The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha and a beta chain , both...

.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. having diverged from DRB1 approximately 4 million years ago.

DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.

Alleles

DR52 recognition of some DRB3* alleles

DRB5*	DR51	?	Sample
allele	%	%	size (N)
0101	>71		28
0102	>86		8
0202	>86		13

DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.








DRB5*01 allele group

• 14 Alleles: 11 proteins, 2 Nulls
• DR51 Serotype: *0101, *0102
• Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
• Nulls: *0108N, *0110N

DRB5*02 allele group

• 4 Alleles: 4 proteins
• DR51 Serotype: *0202,
• Serotype unknown: *0203 to *0205

Associated diseases

DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:

DRB5*0101:DRB1*1501 Multiple sclerosis, leprosy

DRB1 linkage

HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.

HLA-DR2

HLA-DR2

HLA-DR2 of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group...

• HLA-DR15
  HLA-DR15
  HLA-DR15 is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies...
  
   - DRB1*15
• HLA-DR16
  HLA-DR16
  HLA-DR16 is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies...
  
  - DRB1*16