Heat repeat domain
Encyclopedia
The HEAT repeat domain is a protein domain
found in a number of cytoplasmic
proteins including the four that the give rise to the acronym HEAT (Huntingtin
, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast PI3-kinase
TOR1). HEAT repeats form a rod-like helical structures which are involved in intracellular transport.
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
found in a number of cytoplasmic
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
proteins including the four that the give rise to the acronym HEAT (Huntingtin
Huntingtin
The Huntingtin gene, also called HTT or HD gene, is the IT15 gene which codes for a protein called the huntingtin protein...
, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast PI3-kinase
Phosphoinositide 3-kinase
Phosphatidylinositol 3-kinases are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In response to lipopolysaccharide, PI3K phosphorylates p65, inducing...
TOR1). HEAT repeats form a rod-like helical structures which are involved in intracellular transport.