Histone deacetylase 2 - AbsoluteAstronomy.com

Histone deacetylase 2 is an enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

that in humans is encoded by the HDAC2 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

Interactions

Histone deacetylase 2 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

with CHD3

CHD3

Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.-Interactions:CHD3 has been shown to interact with HDAC1, Histone deacetylase 2 and SERBP1.-Further reading:...

, MTA1

MTA1

Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene.-Interactions:MTA1 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, Estrogen receptor alpha and MNAT1.-Further reading:...

, FKBP3

FKBP3

FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.-Interactions:FKBP3 has been shown to interact with YY1, HDAC1, Histone deacetylase 2 and Mdm2.-Further reading:...

, CHD4

CHD4

Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene.-Interactions:CHD4 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related....

, RCOR1

RCOR1

REST corepressor 1 is a protein that in humans is encoded by the RCOR1 gene.-Interactions:RCOR1 has been shown to interact with HMG20B, HDAC1, Histone deacetylase 2, RE1-silencing transcription factor and PHF21A.-Further reading:...

, Retinoblastoma protein

Retinoblastoma protein

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in the majority types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide...

, CDC20

CDC20

The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex , a large 11-13 subunit complex that initiates chromatid separation...

, RBBP4

RBBP4

Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.-Interactions:RBBP4 has been shown to interact with HDAC1, Histone deacetylase 2, SIN3A, Retinoblastoma protein, SAP30, CREB-binding protein, GATAD2B, BRCA1, MTA2 and HDAC3.-Further reading:...

, CDH1

CDH1 (gene)

Cadherin-1 also known as CAM 120/80 or epithelial cadherin or uvomorulin is a protein that in humans is encoded by the CDH1 gene. CDH1 has also been designated as CD324 . It is a tumor suppressor gene.- Function :Cadherin-1 is a classical member of the cadherin superfamily...

, EED

EED

Polycomb protein EED is a protein that in humans is encoded by the EED gene.- Function :Polycomb protein EED is a member of the Polycomb-group family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over...

, GTF2I

GTF2I

General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene.-Interactions:GTF2I has been shown to interact with USF1 , Histone deacetylase 2, PRKG1, Myc, MAPK3, HDAC3, Serum response factor and Bruton's tyrosine kinase.-Further reading:...

, Host cell factor C1

Host cell factor C1

Host cell factor is a protein that in humans is encoded by the HCFC1 gene.-Interactions:Host cell factor C1 has been shown to interact with HDAC1, Histone deacetylase 2, OGT, SIN3A, SUDS3, ZBTB17, Sp1 transcription factor, MLL, PPP1CA, POU2F1, PDCD2, WDR5, CREB3 and GABPA.-Further reading:...

, PHF21A

PHF21A

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.-Interactions:PHF21A has been shown to interact with HMG20B, HDAC1, Histone deacetylase 2 and RCOR1....

, BUB3

BUB3

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint ; though BUB3 is non-essential in yeast, it is essential in higher eukaryotes...

, MXD1

MXD1

MAD protein is a protein that in humans is encoded by the MXD1 gene.-Interactions:MXD1 has been shown to interact with Histone deacetylase 2, SMC3, MLX, SIN3A and MAX.-Further reading:...

, HDAC10

HDAC10

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.-Interactions:HDAC10 has been shown to interact with Histone deacetylase 2 and Nuclear receptor co-repressor 2....

, RELA

RELA

Transcription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...

, Sp3 transcription factor

Sp3 transcription factor

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes...

, DNMT1

DNMT1

DNA -methyltransferase 1 is an enzyme that in humans is encoded by the DNMT1 gene.-Interactions:DNMT1 has been shown to interact with Histone deacetylase 2, DMAP1, PCNA, Retinoblastoma protein, DNMT3A and DNMT3B.-Further reading:...

, SMARCA5

SMARCA5

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.-Interactions:...

, HSPA4

HSPA4

Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family...

, SUV39H1

SUV39H1

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.-Interactions:SUV39H1 has been shown to interact with HDAC9, HDAC1, Histone deacetylase 2, Retinoblastoma protein, CBX5, HDAC3, DNMT3A, MBD1, RUNX1, SBF1 and CBX1.-Further reading:...

, HDAC1

HDAC1

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.-Interactions:HDAC1 has been shown to interact with RAD9A, DNMT3L, MTA1, FKBP3, CDC20, CDH1, Host cell factor C1, BUB3, Nuclear receptor co-repressor 2, IKZF1, Prohibitin, EVI1, DDX5, DNMT3A, Mothers against...

, Methyl-CpG-binding domain protein 2

Methyl-CpG-binding domain protein 2

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.-Interactions:Methyl-CpG-binding domain protein 2 has been shown to interact with HDAC1, Histone deacetylase 2, SIN3A, MIZF, MBD3 and GATAD2B....

, SIN3A

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.-Interactions:SIN3A has been shown to interact with HDAC9, OGT, RBBP7, RBBP4, Host cell factor C1, MXD1, IKZF1, Nuclear receptor co-repressor 2, SAP130, KLF11, Methyl-CpG-binding domain protein 2, HDAC1,...

, SAP30

SAP30

Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene.- Function :Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes...

, SNW1

SNW1

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.-Interactions:SNW1 has been shown to interact with Histone deacetylase 2, SKI protein, Retinoblastoma protein, PABPN1, CIR, RBPJ, Nuclear receptor coactivator 1, Nuclear receptor co-repressor 2, Calcitriol...

, HMG20B

HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.-Interactions:...

, PPP1R8

PPP1R8

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.-Interactions:PPP1R8 has been shown to interact with PPP1CA, Histone deacetylase 2, SF3B1 and EED.-Further reading:...

, Sp1 transcription factor, Ataxia telangiectasia and Rad3 related

Ataxia telangiectasia and Rad3 related

Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein or FRAP-related protein 1 is an enzyme that in humans is encoded by the ATR gene...

, MTA2

MTA2

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.-Interactions:MTA2 has been shown to interact with HDAC1, Histone deacetylase 2, MTA1, CHD4, RBBP7, RBBP4, MBD3 and SATB1....

, TOP2B

TOP2B

DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.-Interactions:TOP2B has been shown to interact with BAZ1B, HDAC1, Histone deacetylase 2, T-cell surface glycoprotein CD3 epsilon chain, Small ubiquitin-related modifier 1 and P53.-Further reading:...

, YY1

YY1

Transcriptional repressor protein YY1 is a protein that in humans is encoded by the YY1 gene.-Interactions:YY1 has been shown to interact with Histone deacetylase 2, FKBP3, ATF6, Myc, SAP30, EP300, HDAC3, NOTCH1 and RYBP....

, EZH2

EZH2

Histone-lysine N-methyltransferase EZH2 is an enzyme that in humans is encoded by the EZH2 gene.This gene encodes a member of the Polycomb-group family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over...

and Mad1

Mad1

Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.-Interactions:...

. GATA4

GATA4

Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.-Interactions:GATA4 has been shown to interact with NKX2-5, TBX5, ZFPM2, Serum response factor and HAND2.HDAC2- External links :...

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