HDAC1
Encyclopedia
Histone deacetylase 1 is an enzyme
that in humans is encoded by the HDAC1 gene
.
with RAD9A
, DNMT3L
, MTA1
, FKBP3
, CDC20
, CDH1
, Host cell factor C1
, BUB3
, Nuclear receptor co-repressor 2
, IKZF1
, Prohibitin
, EVI1
, DDX5
, DNMT3A
, Mothers against decapentaplegic homolog 2
, Histone deacetylase 2
, MIER1
, SIN3A
, Death-associated protein 6, Androgen receptor
, HMG20B
, HUS1
, IFRD1
, MLL
, ING1
, MyoD
, GATA1
, SPEN
, Mad1
, Promyelocytic leukemia protein
, CHD3
, Homeobox protein TGIF1
, Retinoblastoma-like protein 2
, Retinoblastoma-like protein 1
, CHD4
, RCOR1
, RBBP7
, RFC1
, Retinoblastoma protein
, RBBP4
, EED
, PHF21A
, SIN3B
, RELA
, NFKB1
, BUB1B
, Mdm2
, SATB1
, HSPA4
, SUV39H1
, BUB1
, Methyl-CpG-binding domain protein 2
, Zinc finger and BTB domain-containing protein 16
, DDX17
, BCL6
, SUDS3
, SAP30
, Sp1 transcription factor, MTA2
, PCNA
, CBFA2T3
, TOP2B
, MBD3
, CTBP1
, TOP2A
, EZH2
,BTG2
, and COUP-TFII
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the HDAC1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
HDAC1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with RAD9A
RAD9A
Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene.-Interactions:RAD9A has been shown to interact with RAD17, HDAC1, TOPBP1, RAD1 homolog, BCL2-like 1, Bcl-2, Androgen receptor, DNAJC7, HUS1 and Abl gene.-Further reading:...
, DNMT3L
DNMT3L
DNA -methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene.-Further reading:...
, MTA1
MTA1
Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene.-Interactions:MTA1 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, Estrogen receptor alpha and MNAT1.-Further reading:...
, FKBP3
FKBP3
FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.-Interactions:FKBP3 has been shown to interact with YY1, HDAC1, Histone deacetylase 2 and Mdm2.-Further reading:...
, CDC20
CDC20
The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex , a large 11-13 subunit complex that initiates chromatid separation...
, CDH1
CDH1 (gene)
Cadherin-1 also known as CAM 120/80 or epithelial cadherin or uvomorulin is a protein that in humans is encoded by the CDH1 gene. CDH1 has also been designated as CD324 . It is a tumor suppressor gene.- Function :Cadherin-1 is a classical member of the cadherin superfamily...
, Host cell factor C1
Host cell factor C1
Host cell factor is a protein that in humans is encoded by the HCFC1 gene.-Interactions:Host cell factor C1 has been shown to interact with HDAC1, Histone deacetylase 2, OGT, SIN3A, SUDS3, ZBTB17, Sp1 transcription factor, MLL, PPP1CA, POU2F1, PDCD2, WDR5, CREB3 and GABPA.-Further reading:...
, BUB3
BUB3
Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint ; though BUB3 is non-essential in yeast, it is essential in higher eukaryotes...
, Nuclear receptor co-repressor 2
Nuclear receptor co-repressor 2
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target...
, IKZF1
IKZF1
DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia...
, Prohibitin
Prohibitin
Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene.The Phb gene has also been described in animals, fungi, plants, and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1...
, EVI1
EVI1
MDS1 and EVI1 complex locus protein EVI1 also known as ecotropic virus integration site 1 protein homolog or positive regulatory domain zinc finger protein 3 is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine...
, DDX5
DDX5
Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.- Function :...
, DNMT3A
DNMT3A
DNA -methyltransferase 3A is an enzyme that in humans is encoded by the DNMT3A gene.-Interactions:DNMT3A has been shown to interact with ZNF238, HDAC1, Myc, Protein inhibitor of activated STAT2, DNMT1, DNMT3B, PIAS1, UBE2I and SUV39H1....
, Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' and the C....
, Histone deacetylase 2
Histone deacetylase 2
Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.-Interactions:Histone deacetylase 2 has been shown to interact with CHD3, MTA1, FKBP3, CHD4, RCOR1, Retinoblastoma protein, CDC20, RBBP4, CDH1, EED, GTF2I, Host cell factor C1, PHF21A, BUB3, MXD1, HDAC10, RELA, Sp3...
, MIER1
MIER1
Mesoderm induction early response protein 1 is a protein that in humans is encoded by the MIER1 gene.-Further reading:...
, SIN3A
SIN3A
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.-Interactions:SIN3A has been shown to interact with HDAC9, OGT, RBBP7, RBBP4, Host cell factor C1, MXD1, IKZF1, Nuclear receptor co-repressor 2, SAP130, KLF11, Methyl-CpG-binding domain protein 2, HDAC1,...
, Death-associated protein 6, Androgen receptor
Androgen receptor
The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...
, HMG20B
HMG20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.-Interactions:...
, HUS1
HUS1
Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene.-Interactions:HUS1 has been shown to interact with RAD9A, RAD17, HDAC1, RAD1 homolog and PCNA.-Further reading:...
, IFRD1
IFRD1
Interferon-related developmental regulator 1 is a protein that in humans is encoded by the IFRD1 gene. The gene is expressed mostly in neutrophils, skeletal and cardiac muscle, brain, pancreas....
, MLL
MLL (gene)
Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL gene.MLL is a histone methyltransferase deemed a positive global regulator of gene transcription...
, ING1
ING1
Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.-Location on Chromosome 13:ING1 is located near the following genes on Chromosome 13*CARKD Carbohydrate Kinase Domain-Containing Protein...
, MyoD
MyoD
MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...
, GATA1
GATA1
Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene....
, SPEN
SPEN
Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.-Interactions:SPEN has been shown to interact with HDAC1, SRA1 and Nuclear receptor co-repressor 2.-Further reading:...
, Mad1
Mad1
Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.-Interactions:...
, Promyelocytic leukemia protein
Promyelocytic leukemia protein
Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing...
, CHD3
CHD3
Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.-Interactions:CHD3 has been shown to interact with HDAC1, Histone deacetylase 2 and SERBP1.-Further reading:...
, Homeobox protein TGIF1
Homeobox protein TGIF1
Homeobox protein TGIF1 is a protein that in humans is encoded by the TGIF1 gene. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.- Function :...
, Retinoblastoma-like protein 2
Retinoblastoma-like protein 2
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.-Interactions:Retinoblastoma-like protein 2 has been shown to interact with HDAC1, C-Raf, RBBP8, Cyclin E1, Prohibitin, Cyclin-dependent kinase 2, BRF1 and BRCA1....
, Retinoblastoma-like protein 1
Retinoblastoma-like protein 1
Retinoblastoma-like 1 , also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.- Function :The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene...
, CHD4
CHD4
Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene.-Interactions:CHD4 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related....
, RCOR1
RCOR1
REST corepressor 1 is a protein that in humans is encoded by the RCOR1 gene.-Interactions:RCOR1 has been shown to interact with HMG20B, HDAC1, Histone deacetylase 2, RE1-silencing transcription factor and PHF21A.-Further reading:...
, RBBP7
RBBP7
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.-Interactions:RBBP7 has been shown to interact with HDAC1, MTA2, SIN3A, Retinoblastoma protein, SAP30, GATAD2B and BRCA1.-Further reading:...
, RFC1
RFC1
Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.-Interactions:RFC1 has been shown to interact with BRD4, HDAC1, RFC3, RELA and PCNA.-Further reading:...
, Retinoblastoma protein
Retinoblastoma protein
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in the majority types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide...
, RBBP4
RBBP4
Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.-Interactions:RBBP4 has been shown to interact with HDAC1, Histone deacetylase 2, SIN3A, Retinoblastoma protein, SAP30, CREB-binding protein, GATAD2B, BRCA1, MTA2 and HDAC3.-Further reading:...
, EED
EED
Polycomb protein EED is a protein that in humans is encoded by the EED gene.- Function :Polycomb protein EED is a member of the Polycomb-group family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over...
, PHF21A
PHF21A
PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.-Interactions:PHF21A has been shown to interact with HMG20B, HDAC1, Histone deacetylase 2 and RCOR1....
, SIN3B
SIN3B
Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.-Interactions:SIN3B has been shown to interact with HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1.-Further reading:...
, RELA
RELA
Transcription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...
, NFKB1
NFKB1
Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and...
, BUB1B
BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.-Interactions:BUB1B has been shown to interact with AP2B1, HDAC1, BUB3, MAD2L1, Gamma-synuclein, BRCA2 and CDC20.-Further reading:...
, Mdm2
Mdm2
Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain of the p53 tumor suppressor and an inhibitor of...
, SATB1
SATB1
SATB1 is a protein which in humans is encoded by the SATB1 gene.- Function :SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation...
, HSPA4
HSPA4
Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family...
, SUV39H1
SUV39H1
Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.-Interactions:SUV39H1 has been shown to interact with HDAC9, HDAC1, Histone deacetylase 2, Retinoblastoma protein, CBX5, HDAC3, DNMT3A, MBD1, RUNX1, SBF1 and CBX1.-Further reading:...
, BUB1
BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 is an enzyme that in humans is encoded by the BUB1 gene....
, Methyl-CpG-binding domain protein 2
Methyl-CpG-binding domain protein 2
Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.-Interactions:Methyl-CpG-binding domain protein 2 has been shown to interact with HDAC1, Histone deacetylase 2, SIN3A, MIZF, MBD3 and GATAD2B....
, Zinc finger and BTB domain-containing protein 16
Zinc finger and BTB domain-containing protein 16
Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.-Function:This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the...
, DDX17
DDX17
Probable ATP-dependent RNA helicase DDX17 is an enzyme that in humans is encoded by the DDX17 gene.-Interactions:DDX17 has been shown to interact with HDAC1, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Estrogen receptor alpha, Nuclear receptor coactivator 2, SRA1,, DDX5 and...
, BCL6
BCL6
B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.- Function :The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain...
, SUDS3
SUDS3
Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.-Interactions:SUDS3 has been shown to interact with HDAC1, Host cell factor C1, SIN3B and SIN3A.-Further reading:...
, SAP30
SAP30
Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene.- Function :Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes...
, Sp1 transcription factor, MTA2
MTA2
Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.-Interactions:MTA2 has been shown to interact with HDAC1, Histone deacetylase 2, MTA1, CHD4, RBBP7, RBBP4, MBD3 and SATB1....
, PCNA
PCNA
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome...
, CBFA2T3
CBFA2T3
Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.-Interactions:CBFA2T3 has been shown to interact with HDAC1, HDAC3, TCF3, LDB1, TAL1, RUNX1T1 and PRKAR2A.-Further reading:...
, TOP2B
TOP2B
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.-Interactions:TOP2B has been shown to interact with BAZ1B, HDAC1, Histone deacetylase 2, T-cell surface glycoprotein CD3 epsilon chain, Small ubiquitin-related modifier 1 and P53.-Further reading:...
, MBD3
MBD3
Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene.-Interactions:MBD3 has been shown to interact with Aurora A kinase, HDAC1, Methyl-CpG-binding domain protein 2, MTA2 and GATAD2B.-Further reading:...
, CTBP1
CTBP1
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene.- Function :The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation...
, TOP2A
TOP2A
DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.-Interactions:TOP2A has been shown to interact with HDAC1, CDC5L, Small ubiquitin-related modifier 1 and P53.-Further reading:...
, EZH2
EZH2
Histone-lysine N-methyltransferase EZH2 is an enzyme that in humans is encoded by the EZH2 gene.This gene encodes a member of the Polycomb-group family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over...
,BTG2
BTG2
Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene and in other mammals by the homologous Btg2 gene...
, and COUP-TFII
COUP-TFII
COUP-TFII , also known as NR2F2 is a protein that in humans is encoded by the NR2F2 gene...
.