Zinc finger and BTB domain-containing protein 16 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the ZBTB16 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger

Zinc finger

Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...

 transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

 that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle

Cell cycle

The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

 progression, and interacts with a histone deacetylase

Histone deacetylase

Histone deacetylases are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone...

. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia

Acute promyelocytic leukemia

Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia , a cancer of the blood and bone marrow. It is also known as acute progranulocytic leukemia; APL; AML with t, PML-RARA and variants; FAB subtype M3 and M3 variant.In APL, there is an abnormal accumulation of immature...

 (APL) and physiological roles have been identified in mouse Natural Killer T cell

Natural Killer T cell

Natural killer T cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self- and foreign lipids and glycolipids...

s and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.

Interactions

Zinc finger and BTB domain-containing protein 16 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with ZBTB32

ZBTB32

Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the ZBTB32 gene.-Interactions:ZBTB32 has been shown to interact with TXNIP, Fanconi anemia, complementation group C and Zinc finger and BTB domain-containing protein 16.- External links :...

, Heparin-binding EGF-like growth factor

Heparin-binding EGF-like growth factor

Heparin-binding EGF-like growth factor is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.-Interactions:...

, Histone deacetylase 5

Histone deacetylase 5

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.-Interactions:Histone deacetylase 5 has been shown to interact with Zinc finger and BTB domain-containing protein 16, BCL6, CBX5, YWHAQ, Myocyte-specific enhancer factor 2A, Nuclear receptor co-repressor 1, IKZF1,...

, HDAC6

HDAC6

Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene.-Interactions:HDAC6 has been shown to interact with HDAC11 and Zinc finger and BTB domain-containing protein 16.-Further reading: -External links:...

, FHL2

FHL2

Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.-Interactions:FHL2 has been shown to interact with Beta-catenin, Titin, Zinc finger and BTB domain-containing protein 16, Integrin, beta 6, Androgen receptor, ITGA7, CREB1, MAPK1, CD49c, ZNF638, BRCA1,...

, SIN3B

SIN3B

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.-Interactions:SIN3B has been shown to interact with HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1.-Further reading:...

, Nuclear receptor co-repressor 2

Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target...

, Angiotensin II receptor type 1

Angiotensin II receptor type 1

Angiotensin II receptor, type 1 or AT1 receptor is an angiotensin receptor. It has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system...

, HDAC1

HDAC1

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.-Interactions:HDAC1 has been shown to interact with RAD9A, DNMT3L, MTA1, FKBP3, CDC20, CDH1, Host cell factor C1, BUB3, Nuclear receptor co-repressor 2, IKZF1, Prohibitin, EVI1, DDX5, DNMT3A, Mothers against...

, Retinoic acid receptor alpha

Retinoic acid receptor alpha

Retinoic acid receptor alpha , also known as NR1B1 is a nuclear receptor that in humans is encoded by the RARA gene.- Function :...

, SIN3A

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.-Interactions:SIN3A has been shown to interact with HDAC9, OGT, RBBP7, RBBP4, Host cell factor C1, MXD1, IKZF1, Nuclear receptor co-repressor 2, SAP130, KLF11, Methyl-CpG-binding domain protein 2, HDAC1,...

, BCL6

BCL6

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.- Function :The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain...

, RUNX1T1

RUNX1T1

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.-Interactions:RUNX1T1 has been shown to interact with CBFA2T2, Zinc finger and BTB domain-containing protein 16, Nuclear receptor co-repressor 1, Nuclear receptor co-repressor 2, CBFA2T3, GFI1, Calcitriol receptor and...

, HDAC4

HDAC4

Histone deacetylase 4, also known as HDAC4, is a protein which in humans is encoded by the HDAC4 gene.- Function :Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects...

, BMI1

BMI1

BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1 gene.- Function :BMI1 has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes...

, GATA1

GATA1

Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene....

, GATA2

GATA2

GATA binding protein 2, also known as GATA2, is a human gene. The protein encoded by this gene is a transcription factor.The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells...

, Promyelocytic leukemia protein

Promyelocytic leukemia protein

Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing...

 and Calcitriol receptor

Calcitriol receptor

The calcitriol receptor, also known as the vitamin D receptor and also known as NR1I1 , is a member of the nuclear receptor family of transcription factors...

.

Further reading

External links