Integral monotopic protein
Encyclopedia
Three-dimensional structures of the following integral monotopic proteins have been determined:
- prostaglandin H2 syntheses 1 and 2 (cyclooxygenaseCyclooxygenaseCyclooxygenase is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain...
s) - lanosterol synthaseLanosterol synthaseLanosterol synthase is an oxidosqualene cyclase enzyme that converts -2,3-oxidosqualene to a protosterol cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis...
and squalene-hopene cyclase - microsomal prostaglandin E synthaseProstaglandin E synthaseProstaglandin E synthase is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E from prostaglandin H2.The synthase generating PGE2 is a membrane-associated protein....
- carnitine O-palmitoyltransferaseCarnitine O-palmitoyltransferaseCarnitine O-palmitoyltransferase is a mitochondrial transferase enzyme involved in the metabolism of palmitoylcarnitine into palmitoyl-CoA...
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There are also structures of integral monotopic domains of transmembrane proteins:
- monoamine oxidaseMonoamine oxidaseL-Monoamine oxidases are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was originally discovered by Mary Bernheim in the liver and was named tyramine oxidase...
s A and B - fatty acid amide hydrolase
- mammalian cytochrome P450 oxidaseCytochrome P450 oxidaseThe cytochrome P450 superfamily is a large and diverse group of enzymes. The function of most CYP enzymes is to catalyze the oxidation of organic substances. The substrates of CYP enzymes include metabolic intermediates such as lipids and steroidal hormones, as well as xenobiotic substances...
s - corticosteroid 11-beta-dehydrogenases11Beta Hydroxysteroid dehydrogenase11β-Hydroxysteroid dehydrogenase is the name of a family of enzymes that catalyze the conversion of inert 11 keto-products to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors.-Function:Cortisol, a glucocorticoid, binds the glucocorticoid...