MAPK8
Encyclopedia
Mitogen-activated protein kinase 8 is an enzyme
that in humans is encoded by the MAPK8 gene
.
with SPIB
, DUSP1
, Activating transcription factor 2
, SH3BP5
, GSTP1
, MAPK8IP1
, MAP2K7
, CRK
, MAP2K4
, DUSP22
, Myc
, MAP3K2
, DUSP10
, REL
, MAPK8IP3
, IRS1
, MAP3K1
and C-jun
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the MAPK8 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
MAPK8 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with SPIB
SPIB
Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.-Interactions:SPIB has been shown to interact with MAPK3 and MAPK8....
, DUSP1
DUSP1
Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.-Interactions:DUSP1 has been shown to interact with MAPK14, MAPK1 and MAPK8.-Further reading:...
, Activating transcription factor 2
Activating transcription factor 2
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.-Function:This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element , an octameric...
, SH3BP5
SH3BP5
SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.-Interactions:SH3BP5 has been shown to interact with Bruton's tyrosine kinase and MAPK8.-Further reading:...
, GSTP1
GSTP1
Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.-Interactions:GSTP1 has been shown to interact with Fanconi anemia, complementation group C and MAPK8.-Further reading:...
, MAPK8IP1
MAPK8IP1
C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.-Interactions:MAPK8IP1 has been shown to interact with MAP3K10, DUSP16, Mitogen-activated protein kinase 9, MAPK8, LRP2, LRP1, MAP3K12, MAP2K7, MAPK8IP2 and MAP3K11.-Further reading:...
, MAP2K7
MAP2K7
Mitogen-activated protein kinase kinase 7, also known as MAP2K7, is ahuman gene.-Interactions:MAP2K7 has been shown to interact with GADD45B, MAPK8, MAPK8IP3, MAPK8IP1, MAP3K12, MAP3K2, MAPK8IP2 and DUSP19.-Further reading:...
, CRK
CRK (gene)
Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene.- Function :...
, MAP2K4
MAP2K4
Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.-Interactions:MAP2K4 has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.-Further reading:...
, DUSP22
DUSP22
Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.-Interactions:DUSP22 has been shown to interact with MAPK1 and MAPK8.-Further reading:...
, Myc
Myc
Myc is a regulator gene that codes for a transcription factor. In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences and recruiting histone acetyltransferases...
, MAP3K2
MAP3K2
Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.-Interactions:MAP3K2 has been shown to interact with SH2D2A, MAP2K7, MAP2K5, XIAP and MAPK8.-Further reading:...
, DUSP10
DUSP10
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.-Interactions:DUSP10 has been shown to interact with MAPK14 and MAPK8.-Further reading:...
, REL
REL
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell...
, MAPK8IP3
MAPK8IP3
C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.-Interactions:MAPK8IP3 has been shown to interact with ASK1, C-Raf, PTK2, MAPK10, Mitogen-activated protein kinase 9, MAPK8, MAP2K1, KLC2, MAP2K7, KLC1, MAPK8IP2 and MAP2K4.-Further reading:...
, IRS1
IRS1
Insulin receptor substrate 1 is a protein that in humans is encoded by the IRS-1 gene.-Function:Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 receptors to intracellular pathways PI3K / Akt and Erk MAP kinase...
, MAP3K1
MAP3K1
Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.-Interactions:MAP3K1 has...
and C-jun
C-jun
c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...
.