PRKC, apoptosis, WT1, regulator, also known as PAWR or Prostate apoptosis response-4 (Par-4), is a human gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 coding for a tumor-suppressor protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that induces apoptosis

Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...

 in cancer

Cancer

Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...

 cells, but not in normal cells.
The active domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

 of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance.

Interactions

PAWR has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with WT1

WT1

Wilms tumor protein is a protein that in humans is encoded by the WT1 gene.- Function :This gene encodes a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine-rich DNA-binding domain at the N-terminus...

, THAP1

THAP1

THAP domain-containing protein 1 is a protein that in humans is encoded by the THAP1 gene.-External links:...

, SLC5A1

SLC5A1

Sodium/glucose cotransporter 1 is a protein that in humans is encoded by the SLC5A1 gene.- Cloning of the sodium-glucose cotransporter SGLT1 :...

, DAPK3

DAPK3

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.-Interactions:DAPK3 has been shown to interact with PAWR and Death associated protein 6.-Further reading:...

, Apoptosis antagonizing transcription factor

Apoptosis antagonizing transcription factor

Protein AATF is a protein that in humans is encoded by the AATF gene.-Interactions:Apoptosis-antagonizing transcription factor has been shown to interact with Sp1 transcription factor, POLR2J, PAWR and Retinoblastoma protein.- External links :...

 and Protein kinase Mζ.

Further reading