The Pamlico were a Native American

Native Americans in the United States

Native Americans in the United States are the indigenous peoples in North America within the boundaries of the present-day continental United States, parts of Alaska, and the island state of Hawaii. They are composed of numerous, distinct tribes, states, and ethnic groups, many of which survive as...

 people of North Carolina

North Carolina

North Carolina is a state located in the southeastern United States. The state borders South Carolina and Georgia to the south, Tennessee to the west and Virginia to the north. North Carolina contains 100 counties. Its capital is Raleigh, and its largest city is Charlotte...

. They spoke an Algonquian

Algonquian languages

The Algonquian languages also Algonkian) are a subfamily of Native American languages which includes most of the languages in the Algic language family. The name of the Algonquian language family is distinguished from the orthographically similar Algonquin dialect of the Ojibwe language, which is a...

 language also known as Pamlico or Carolina Algonquian

Carolina Algonquian language

Carolina Algonquian is an extinct Algonquian language of the Eastern Algonquian subgroup formerly spoken in North Carolina, United States....

.
The Pamlico Indians lived on the Pamlico River

Pamlico River

The Pamlico River is a tidal river that flows into Pamlico Sound, in North Carolina in the United States of America. It is formed by the confluence of the Tar River and Tranters Creek....

 in North Carolina. Named after them were Pamlico Sound

Pamlico Sound

Pamlico Sound in North Carolina, is the largest lagoon along the U.S. East Coast, being long and 24 to 48 km wide. It is a body of water separated from the Atlantic Ocean by the Outer Banks, a row of low, sandy barrier islands, including Cape Hatteras. The Neuse and Pamlico rivers flow in...

, the largest sound in North Carolina, and Pamlico County

Pamlico County, North Carolina

-Demographics:As of the census of 2000, there were 12,934 people, 5,178 households, and 3,717 families residing in the county. The population density was 38 people per square mile . There were 6,781 housing units at an average density of 20 per square mile...

. They are one of the most southerly Algonquian

Algonquian languages

The Algonquian languages also Algonkian) are a subfamily of Native American languages which includes most of the languages in the Algic language family. The name of the Algonquian language family is distinguished from the orthographically similar Algonquin dialect of the Ojibwe language, which is a...

 tribes on the Atlantic seaboard, and the most southerly one for which scholars collected a vocabulary.
In 1696, smallpox

Smallpox

Smallpox was an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning "spotted", or varus, meaning "pimple"...

, called "A great Mortality", devastated the Pamlico and neighboring Algonquian communities and reduced their populations.