Pyridinylpiperazine
Encyclopedia
1-piperazine is a chemical compound
and piperazine
derivative. Some derivatives of this substance are known to act as potent
and selective
a2-adrenergic receptor
antagonist
s, such as 1-(3-fluoro-2-pyridinyl)piperazine.
A few pyridinylpiperazine derivatives are drug
s, including:
Chemical compound
A chemical compound is a pure chemical substance consisting of two or more different chemical elements that can be separated into simpler substances by chemical reactions. Chemical compounds have a unique and defined chemical structure; they consist of a fixed ratio of atoms that are held together...
and piperazine
Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste....
derivative. Some derivatives of this substance are known to act as potent
Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity. A highly potent drug evokes a larger response at low concentrations, while a drug of lower potency evokes a small response at low concentrations...
and selective
Binding selectivity
Binding selectivity refers to the differing affinities with which different ligands bind to a substrate forming a complex. A selectivity coefficient is the equilibrium constant for the reaction of displacement by one ligand of another ligand in a complex with the substrate...
a2-adrenergic receptor
Alpha-2 adrenergic receptor
The alpha-2 adrenergic receptor is a G protein-coupled receptor associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well...
antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
s, such as 1-(3-fluoro-2-pyridinyl)piperazine.
A few pyridinylpiperazine derivatives are drug
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
s, including:
- AzaperoneAzaperoneAzaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. It is used mainly in pigs and elephants. More rarely it may be used in humans as an antipsychotic drug, but this is uncommon...
- Antipsychotic - AtevirdineAtevirdineAteviridine is non-nucleoside reverse transcriptase inhibitor that has been studied for the treatment of HIV....
Antiretroviral
See also
- Pyrimidinylpiperazine
- PhenylpiperazinePhenylpiperazine1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix '-piprazole' is sometimes used in the names of drugs to indicate they belong to this class....
- DiphenylmethylpiperazineDiphenylmethylpiperazine1-piperazine, also known as benzhydrylpiperazine, is a chemical compound and piperazine derivative. It features a piperazine ring with a benzhydryl group bound to one of the nitrogens....
- BenzylpiperazineBenzylpiperazineBenzylpiperazine is a recreational drug with euphoric, stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity, and seizures...