RhoGEF domain is a structural domain of guanine nucleotide exchange factor

Guanine nucleotide exchange factor

Guanine nucleotide exchange factors activate monomeric GTPases by stimulating the release of guanosine diphosphate to allow binding of guanosine triphosphate . A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity...

s for Rho

Rho

Rho is the 17th letter of the Greek alphabet. In the system of Greek numerals, it has a value of 100. It is derived from Semitic resh "head"...

/Rac

RAC

-Companies:* Rent-A-Center, an American public furniture and electronics rent to own company* Royal Automobile Club, a private club in Pall Mall, London* RAC plc, a breakdown company in the United Kingdom...

/Cdc42

CDC42

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...

-like GTPase

GTPase

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...

s. It is also called "Dbl-homologous" (DH) domain.

Human proteins containing this domain

ABR; AKAP13

AKAP13

A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.-Interactions:AKAP13 has been shown to interact with Estrogen receptor alpha, CTNNAL1 and PRKAR2A.-Further reading:...

; ARHGEF1

ARHGEF1

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.-Interactions:ARHGEF1 has been shown to interact with GNA13, CD44, P110α and GNA12.-Further reading:...

; ARHGEF10

ARHGEF10

Rho guanine nucleotide exchange factor 10 is a protein that in humans is encoded by the ARHGEF10 gene.-Further reading:...

; ARHGEF10L; ARHGEF11

ARHGEF11

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.-Interactions:ARHGEF11 has been shown to interact with PLXNB3, PLXNB1, PLXNB2 and RHOA.-Further reading:...

; ARHGEF12

ARHGEF12

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.-Interactions:ARHGEF12 has been shown to interact with Insulin-like growth factor 1 receptor, GNA13, PLXNB1, GNA12, TEC and RHOA.-Further reading:...

; ARHGEF15;
ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2

ARHGEF2

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.-Further reading:...

; ARHGEF3

ARHGEF3

Rho guanine nucleotide exchange factor 3, also known as ARHGEF3, is a human gene.-Interactions:ARHGEF3 has been shown to interact with RHOB and RHOA.-Further reading:...

; ARHGEF4

ARHGEF4

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.-Interactions:ARHGEF4 has been shown to interact with APC.-Further reading:...

; ARHGEF5

ARHGEF5

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.-Further reading:...

;
ARHGEF6

ARHGEF6

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.-Further reading:...

; ARHGEF7

ARHGEF7

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.-Interactions:ARHGEF7 has been shown to interact with GIT1, SHANK3, Cbl gene, SHANK1 and SHANK2.-External links:* Info with links in the...

; ARHGEF9

ARHGEF9

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.-Interactions:ARHGEF9 has been shown to interact with GPHN and SMURF1.-Further reading:...

; ASEF2; BCR

BCR gene

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.-Pathology:...

; C9orf100; DEPDC2; DNMBP;
ECT2

ECT2

Protein ECT2 is a protein that in humans is encoded by the ECT2 gene.-Further reading:...

; FARP1

FARP1

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.-Further reading:...

; FARP2

FARP2

FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.-Further reading:...

; FGD1

FGD1

FYVE, RhoGEF and PH domain-containing protein 1 also known as faciogenital dysplasia 1 protein , zinc finger FYVE domain-containing protein 3 , or Rho/Rac guanine nucleotide exchange factor FGD1 is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome...

; FGD2

FGD2

FYVE, RhoGEF and PH domain-containing protein 2 , also known as zinc finger FYVE domain-containing protein 4 , is a protein that in humans is encoded by the FGD2 gene.It is a member of the FYVE, RhoGEF and PH domain containing family....

; FGD3

FGD3

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.-Further reading:...

; FGD4

FGD4

FYVE, RhoGEF and PH domain-containing protein 4 is a protein that in humans is encoded by the FGD4 gene.-External links:*...

; FGD5;
FGD6; GEFT

GEFT

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.-Further reading:...

; ITSN1

ITSN1

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.-Interactions:ITSN1 has been shown to interact with SNAP-25, SOS1, SCAMP1 and CDC42.-Further reading:...

; ITSN2

ITSN2

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.-Interactions:ITSN2 has been shown to interact with Wiskott-Aldrich syndrome protein.-Further reading:...

; KALRN; LFDH; MCF2

MCF2

Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.-Further reading:...

; MCF2L

MCF2L

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.-Further reading:...

;
MCF2L2; NET1

NET1

Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene.-Further reading:...

; NGEF; OBSCN

OBSCN

Obscurin is a protein that in humans is encoded by the OBSCN gene.-Interactions:OBSCN has been shown to interact with Titin and ANK1.-Further reading:...

; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4

PLEKHG4

Puratrophin-1 is a protein that in humans is encoded by the PLEKHG4 gene.-Further reading:...

;
PLEKHG5; PLEKHG6; PREX1

PREX1

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.- Function :...

; RASGRF1; SGEF

SGEF

SGEF is a 97 kDa protein involved in intracellular signalling networks. It functions as a guanine nucleotide exchange factor for RhoG, a small G protein of the Rho family.-Discovery:...

; SOS1

SOS1

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.Recent studies also show that mutations in Sos1 can cause Noonan syndrome and hereditary gingival fibromatosis type 1. Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes...

; SOS2; SPATA13;
TIAM1; TIAM2; TRIO

TRIO (gene)

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.-Interactions:TRIO has been shown to interact with Filamin and RHOA.-Further reading:...

; VAV1

VAV1

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.-Interactions:VAV1 has been shown to interact with Ku70, PLCG1, Lymphocyte cytosolic protein 2, Janus kinase 2, SIAH2, S100B, Abl gene, ARHGDIB, SHB, PIK3R1, PRKCQ, Grb2, MAPK1, Syk, Linker of activated T cells, Cbl gene and...

; VAV2

VAV2

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.-Interactions:VAV2 has been shown to interact with CD19 and Grb2.-Further reading:...

; VAV3

VAV3

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.-Further reading:...

;