Wrch1
Encyclopedia
RhoU is a small (~21 kDa) signaling G protein
(more specifically a GTPase
), and is a member of the Rho family of GTPases
.
Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene .
RhoU/Wrch delineates with RhoV/Chp
a Rho subclass related to Rac
and Cdc42
, which emerged in early multicellular organisms during evolution .
Further reading: Rho family of GTPases
G protein
G proteins are a family of proteins involved in transmitting chemical signals outside the cell, and causing changes inside the cell. They communicate signals from many hormones, neurotransmitters, and other signaling factors. G protein-coupled receptors are transmembrane receptors...
(more specifically a GTPase
GTPase
GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...
), and is a member of the Rho family of GTPases
Rho family of GTPases
The Rho family of GTPases is a family of small signaling G protein , and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants...
.
Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene .
RhoU/Wrch delineates with RhoV/Chp
Chp (GTPase)
RhoV is a small signaling G protein , and is a member of the Rho family of GTPases.Chp was identified in 1998 as a GTPase interacting with the p21 activated kinase PAK2 ....
a Rho subclass related to Rac
Rac (GTPase)
Rac is a subfamily of the Rho family of GTPases, small signaling G proteins .The subgroup include:*Rac1*Rac2*Rac3*RhoG...
and Cdc42
CDC42
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...
, which emerged in early multicellular organisms during evolution .
Further reading: Rho family of GTPases
Rho family of GTPases
The Rho family of GTPases is a family of small signaling G protein , and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants...