RhoV is a small (~21 kDa) signaling G protein

G protein

G proteins are a family of proteins involved in transmitting chemical signals outside the cell, and causing changes inside the cell. They communicate signals from many hormones, neurotransmitters, and other signaling factors. G protein-coupled receptors are transmembrane receptors...

 (more specifically a GTPase

GTPase

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...

), and is a member of the Rho family of GTPases

Rho family of GTPases

The Rho family of GTPases is a family of small signaling G protein , and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants...

.
Chp was identified in 1998 as a GTPase interacting with the p21 activated kinase PAK2 .
RhoV/Chp delineates with RhoU/Wrch

Wrch1

RhoU is a small signaling G protein , and is a member of the Rho family of GTPases.Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene ....

 a Rho subclass related to Rac

Rac (GTPase)

Rac is a subfamily of the Rho family of GTPases, small signaling G proteins .The subgroup include:*Rac1*Rac2*Rac3*RhoG...

 and Cdc42

CDC42

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...

, which emerged in early multicellular organisms during evolution .
RhoV/Chp depends on palmitoylation rather than prenylation for association with plasma and intracellular membranes .
In Xenopus embryos, RhoV is encoded by a canonical Wnt response gene and is induced in the developing neural crest at specification. RhoV activity cooperates with the Snai1

SNAI1

Zinc finger protein SNAI1 is a protein that in humans is encoded by the SNAI1 gene.-Interactions:SNAI1 has been shown to interact with CTDSPL, CTDSP1 and CTDSP2.-Further reading:...

 (Snail) transcription factor for the subsequent induction of the pro-invasive transcription factors Snai2

SNAI2

Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene.-Further reading:...

 (Slug), Sox9

SOX9

Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.- Function :SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins...

 or Twist

Twist transcription factor

Twist transcription factor is a basic-helix-loop-helix transcription factor associated with Saethre-Chotzen syndrome.-Interactions:Twist transcription factor has been shown to interact with EP300, TCF3 and PCAF.-External links:*...

.
Further reading: Rho family of GTPases

Rho family of GTPases

The Rho family of GTPases is a family of small signaling G protein , and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants...