Sanofi-Aventis
Encyclopedia
Sanofi S.A. is a multinational
Multinational corporation
A multi national corporation or enterprise , is a corporation or an enterprise that manages production or delivers services in more than one country. It can also be referred to as an international corporation...

 pharmaceutical company headquartered in Paris
Paris
Paris is the capital and largest city in France, situated on the river Seine, in northern France, at the heart of the Île-de-France region...

, France
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...

, the world's fourth-largest by prescription
Prescription drug
A prescription medication is a licensed medicine that is regulated by legislation to require a medical prescription before it can be obtained. The term is used to distinguish it from over-the-counter drugs which can be obtained without a prescription...

 sales. Sanofi engages in the research and development
Research and development
The phrase research and development , according to the Organization for Economic Co-operation and Development, refers to "creative work undertaken on a systematic basis in order to increase the stock of knowledge, including knowledge of man, culture and society, and the use of this stock of...

, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the firm also develops over-the-counter medication
Over-the-counter drug
Over-the-counter drugs are medicines that may be sold directly to a consumer without a prescription from a healthcare professional, as compared to prescription drugs, which may be sold only to consumers possessing a valid prescription...

. The company covers 7 major therapeutic areas: cardiovascular
Circulatory system
The circulatory system is an organ system that passes nutrients , gases, hormones, blood cells, etc...

, central nervous system
Central nervous system
The central nervous system is the part of the nervous system that integrates the information that it receives from, and coordinates the activity of, all parts of the bodies of bilaterian animals—that is, all multicellular animals except sponges and radially symmetric animals such as jellyfish...

, diabetes, internal medicine
Internal medicine
Internal medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. Physicians specializing in internal medicine are called internists. They are especially skilled in the management of patients who have undifferentiated or multi-system disease processes...

, oncology
Oncology
Oncology is a branch of medicine that deals with cancer...

, thrombosis
Thrombosis
Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot to prevent blood loss...

 and vaccine
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...

s (it is the world's largest producer of the latter through its subsidiary Sanofi Pasteur
Sanofi pasteur
Sanofi Pasteur is the vaccines division of sanofi-aventis Group. It is the largest company in the world devoted entirely to vaccines.- History :...

). Sanofi is a full member of the European Federation of Pharmaceutical Industries and Associations
European Federation of Pharmaceutical Industries and Associations
European Federation of Pharmaceutical Industries and Associations is a Brussels-based trade union founded in 1978 representing the research-based pharmaceutical industry operating in Europe....

 (EFPIA).

The company was formed as Sanofi-Aventis in 2004 by the merger of Aventis
Aventis
Aventis was a pharmaceutical and lab assay testing company. It was formed in 1999 when Rhône-Poulenc S.A. merged with Hoechst AG. The merged company was based in Strasbourg, France. With its headquarters in Strasbourg, Aventis was the product of the first transnational merger to combine large...

 and Sanofi-Synthélabo
Sanofi-Synthélabo
Sanofi-Synthélabo was a Paris-based pharmaceutical company formed in 1999, when Sanofi merged with Synthélabo. Sanofi-Aventis was formed in 2004 when Sanofi-Synthélabo merged with Aventis.Sanofi was created in 1973....

. It changed its name to Sanofi in May 2011.

Sanofi-Synthélabo

Sanofi-Synthélabo was formed in 1999 when Sanofi (former subsidiary of Total
Total S.A.
Total S.A. is a French multinational oil company and one of the six "Supermajor" oil companies in the world.Its businesses cover the entire oil and gas chain, from crude oil and natural gas exploration and production to power generation, transportation, refining, petroleum product marketing, and...

) merged with Synthélabo (former subsidiary of L'Oréal
L'Oréal
The L'Oréal Group is the world's largest cosmetics and beauty company. With its registered office in Paris and head office in the Paris suburb of Clichy, Hauts-de-Seine, France, it has developed activities in the field of cosmetics...

). The merged company was based in Paris, France.

Aventis

Aventis was formed in 1999 when French company Rhône-Poulenc
Rhône-Poulenc
-History of the company:The Company was founded in 1928 through the merger of Société des Usines Chimiques du Rhône from Lyon and Établissements Poulenc Frères from Paris founded by Étienne Poulenc, a 19th century Parisian apothecary and brought to prominence by his second and third sons Emile...

 S.A. merged with the German corporation Hoechst Marion Roussel, which itself was formed from the 1995 merger of Hoechst AG
Hoechst AG
Hoechst AG was a German chemicals then life-sciences company that became Aventis Deutschland after its merger with France's Rhône-Poulenc S.A. in 1999...

 with Roussel Uclaf
Roussel Uclaf
Roussel Uclaf S.A. was the second largest French pharmaceutical company before it was acquired by Hoechst AG of Frankfurt, Germany in 1997, with pharmaceutical operations combined into the Hoechst Marion Roussel division...

 and Marion Merrell Dow
Marion Merrell Dow
Marion Merrell Dow and its predecessor Marion Laboratories was a U.S. pharmaceutical company based in Kansas City, Missouri from 1950 until 1996....

. The merged company was based in Schiltigheim
Schiltigheim
Schiltigheim is a commune in the Bas-Rhin department in Alsace in north-eastern France.The inhabitants are called Schilikois in French and Scheligemer in Alsatian....

, near Strasbourg
Strasbourg
Strasbourg is the capital and principal city of the Alsace region in eastern France and is the official seat of the European Parliament. Located close to the border with Germany, it is the capital of the Bas-Rhin département. The city and the region of Alsace are historically German-speaking,...

, France.

Merger and beyond

Sanofi-Aventis was formed in 2004 when Sanofi-Synthélabo
Sanofi-Synthélabo
Sanofi-Synthélabo was a Paris-based pharmaceutical company formed in 1999, when Sanofi merged with Synthélabo. Sanofi-Aventis was formed in 2004 when Sanofi-Synthélabo merged with Aventis.Sanofi was created in 1973....

 acquired Aventis
Aventis
Aventis was a pharmaceutical and lab assay testing company. It was formed in 1999 when Rhône-Poulenc S.A. merged with Hoechst AG. The merged company was based in Strasbourg, France. With its headquarters in Strasbourg, Aventis was the product of the first transnational merger to combine large...

. In early 2004, Sanofi-Synthélabo made a hostile takeover
Takeover
In business, a takeover is the purchase of one company by another . In the UK, the term refers to the acquisition of a public company whose shares are listed on a stock exchange, in contrast to the acquisition of a private company.- Friendly takeovers :Before a bidder makes an offer for another...

 bid worth €47.8 billion for Aventis. Initially, Aventis rejected the bid because it felt that the bid offered inferior value based on the company's share value. The three-month takeover battle concluded when Sanofi-Synthélabo launched a friendly bid of €54.5 billion in place of the previously rejected hostile bid. French government intervention also played an active role. The French
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...

 government, desiring what they called a "local solution", put heavy pressure on Sanofi-Synthélabo to raise its bid for Aventis after it became known that Novartis
Novartis
Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...

, a Swiss
Switzerland
Switzerland name of one of the Swiss cantons. ; ; ; or ), in its full name the Swiss Confederation , is a federal republic consisting of 26 cantons, with Bern as the seat of the federal authorities. The country is situated in Western Europe,Or Central Europe depending on the definition....

 pharmaceutical company, was in the running.

October 2010: Sanofi-Aventis SA will lay off 1,700 US employees due to restructuring triggered by growing generic competition and other factors. The cuts being completed throughout 2011 according to transition needs. The layoffs amount to about 25 percents of the workers in the company's US pharmaceutical business. The company deny the action is related with acquisition plan of buying US biotech firm Genzyme
Genzyme
Genzyme Corporation is a fully owned subsidiary of Sanofi-Aventis. Before its acquisition, Genzyme was an American biotechnology company based in Cambridge, Massachusetts. In 2010, Genzyme was the world’s third-largest biotechnology company, employing more than 11,000 people around the world...

 Corp.

The company dropped the -Aventis suffix of its name on 6 May 2011 after receiving approval at its AGM
Annual general meeting
An annual general meeting is a meeting that official bodies, and associations involving the public , are often required by law to hold...

. The reason given by the company for the change was to make its name easier to pronounce in countries such as China.

Products

  • Alfuzosin
    Alfuzosin
    Alfuzosin is an α1 receptor antagonist used to treat benign prostatic hyperplasia . It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate....

     (Xatral) for benign prostatic hyperplasia
    Benign prostatic hyperplasia
    Benign prostatic hyperplasia also known as benign prostatic hypertrophy , benign enlargement of the prostate , and adenofibromyomatous hyperplasia, refers to the increase in size of the prostate....

  • Biprofined for pain
  • Clopidogrel
    Clopidogrel
    Clopidogrel is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix. The drug works by irreversibly...

     (Plavix, Iscover) for atherothrombosis
  • Codeine
    Codeine
    Codeine or 3-methylmorphine is an opiate used for its analgesic, antitussive, and antidiarrheal properties...

     (Solpadol) for Chronic pain
    Chronic pain
    Chronic pain has several different meanings in medicine. Traditionally, the distinction between acute and chronic pain has relied upon an arbitrary interval of time from onset; the two most commonly used markers being 3 months and 6 months since the initiation of pain, though some theorists and...

  • Docetaxel (Taxotere) for breast
    Breast cancer
    Breast cancer is cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas; those originating from lobules are known as lobular carcinomas...

    , lung
    Lung cancer
    Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue and, eventually, into other parts of the body. Most cancers that start in lung, known as primary...

     and prostate cancer
    Prostate cancer
    Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly...

  • Enoxaparin
    Enoxaparin
    Enoxaparin is a low molecular weight heparin marketed under the trade names Lovenox and Clexane, among others. It is an anticoagulant used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection...

     (Lovenox, Clexane) for thrombosis (its biggest seller in 2008)
  • Fexofenadine
    Fexofenadine
    Fexofenadine is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms...

     (Allegra, Telfast) and Triamcinolone
    Triamcinolone
    Triamcinolone is a long-acting synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream....

     (Nasacort) for allergic rhinitis
    Allergic rhinitis
    Allergic rhinitis, also known as pollenosis or hay fever, is an allergic inflammation of the nasal airways.It occurs when an allergen, such as pollen, dust or animal dander is inhaled by an individual with a sensitized immune system...

  • Glatiramer acetate
    Glatiramer acetate
    Glatiramer acetate is an immunomodulator drug currently used to treat multiple sclerosis...

     (Copaxone) for multiple sclerosis
    Multiple sclerosis
    Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

  • Insulin glulisine
    Insulin glulisine
    Insulin glulisine is a rapid-acting insulin analogue that differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. Chemically, it is 3B-lysine-29B-glutamic acid-human insulin, has the empirical...

     (Apidra) and Insulin glargine
    Insulin glargine
    Insulin glargine, marketed by Sanofi-Aventis under the name Lantus, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. It consists of microcrystals that slowly release insulin, giving a long duration of action of 18 to 26 hours,...

     (Lantus) for diabetes
  • Irbesartan
    Irbesartan
    Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Irbesartan was developed by Sanofi Research...

     (Aprovel, Avapro, Delix, Karvea, Triatec, Tritace) for hypertension
    Hypertension
    Hypertension or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated. What that means is that the heart is having to work harder than it should to pump the blood around the body. Blood pressure involves two measurements, systolic and...

  • Menactra for meningitis
    Meningitis
    Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs...

  • Oxaliplatin
    Oxaliplatin
    Oxaliplatin is a coordination complex that is used in cancer chemotherapy. These platinum-based drugs are usually classified as alkylating agents, although they are not actually alkylating groups ....

     (Eloxatin) for colorectal cancer
    Colorectal cancer
    Colorectal cancer, commonly known as bowel cancer, is a cancer caused by uncontrolled cell growth , in the colon, rectum, or vermiform appendix. Colorectal cancer is clinically distinct from anal cancer, which affects the anus....

  • Risedronic acid (Actonel) for osteoporosis
    Osteoporosis
    Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is deteriorating, and the amount and variety of proteins in bone is altered...

     and Paget’s disease
    Paget's disease of bone
    Paget's disease is a chronic disorder that can result in enlarged and misshapen bones. The excessive breakdown and formation of bone tissue causes affected bone to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints near the affected bones...

  • Valproic acid
    Valproic acid
    Valproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches and schizophrenia...

     (Depakine) and Valproate semisodium
    Valproate semisodium
    Valproate semisodium or divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder...

     (Depakote) for epilepsy
    Epilepsy
    Epilepsy is a common chronic neurological disorder characterized by seizures. These seizures are transient signs and/or symptoms of abnormal, excessive or hypersynchronous neuronal activity in the brain.About 50 million people worldwide have epilepsy, and nearly two out of every three new cases...

  • Zolpidem
    Zolpidem
    Zolpidem is a prescription medication used for the short-term treatment of insomnia, as well as some brain disorders. It is a short-acting nonbenzodiazepine hypnotic of the imidazopyridine class that potentiates gamma-aminobutyric acid , an inhibitory neurotransmitter, by binding to GABAA...

     (Ambien, Ambien CR, Myslee, Stilnoct, Stilnox, Zolfresh, Zolt) for insomnia
    Insomnia
    Insomnia is most often defined by an individual's report of sleeping difficulties. While the term is sometimes used in sleep literature to describe a disorder demonstrated by polysomnographic evidence of disturbed sleep, insomnia is often defined as a positive response to either of two questions:...



The company also produces a broad range of over-the-counter products, among them Allegra
Allegra
Allegra may refer to:A character* Allegra, the main character on the 1994–1996 Nick Jr. television series Allegra's Window* Allegra Geller, fictional character in the 1999 film eXistenZA person...

, IcyHot
IcyHot
IcyHot is a topical rubefacient heat rub meant for relieving pains such as arthritis, backache, muscle strains, sprains, bruises, and cramps. IcyHot, produced and marketed by Chattem, now a subsidiary of Sanofi-Aventis, is known for its dual action pain relief, claiming it is "Icy to dull the...

 for muscle pain, Gold Bond
Gold Bond medicated powder
Gold Bond is a brand of over-the-counter skin care products produced by Chattem of Chattanooga, Tennessee, now a subsidiary of the French pharmaceutical company Sanofi-Aventis. It is available as both a powder and a topical cream. Gold Bond is used to curb moisture, control odor, and soothe minor...

 for skin irritation, and Selsun Blue
Selsun Blue
Selsun Blue is an over-the-counter brand of dandruff shampoo now owned by Sanofi-Aventis. First made by Abbott Laboratories, the brand was bought in Chattem in 2002. Chattem was acquired by Sanofi-Aventis in 2010. Selsun Blue has been marketed as a more effective alternative to brand leader Head &...

 dandruff shampoo (these three brands were acquired in 2010 when Sanofi-Aventis purchased Chattem
Chattem
Chattem is a Chattanooga, Tennessee, producer and marketer of over-the-counter healthcare products, toiletries, dietary supplements, topical analgesics, and medicated skin care products...

).

Management

  • Serge Weinberg, Chairman
    Chairman of the Board
    The Chairman of the Board is a seat of office in an organization, especially of corporations.Chairman of the Board may also refer to:*Chairman of the Board , a 1998 film*Chairmen of the Board , a 1970s American soul music group...

  • Chris Viehbacher, CEO
  • Jean-François Dehecq was the General Manager
    General manager
    General manager is a descriptive term for certain executives in a business operation. It is also a formal title held by some business executives, most commonly in the hospitality industry.-Generic usage:...

     of Sanofi from its creation in 1973 until 2007.

Stockholders

As of 31 January 2011:
  • Breakdown of share ownership: 5.16% by Total
    Total S.A.
    Total S.A. is a French multinational oil company and one of the six "Supermajor" oil companies in the world.Its businesses cover the entire oil and gas chain, from crude oil and natural gas exploration and production to power generation, transportation, refining, petroleum product marketing, and...

    , 9.02% by L'Oréal
    L'Oréal
    The L'Oréal Group is the world's largest cosmetics and beauty company. With its registered office in Paris and head office in the Paris suburb of Clichy, Hauts-de-Seine, France, it has developed activities in the field of cosmetics...

    , 0.46% treasury shares and 1.43% employees. The remaining 83.93% are publicly traded.
  • Voting rights distribution: 8.89% to Total, 15.61% to L'Oréal, 2.33% to employees, and 73.17% to the public.

Head office

The head office is located in the 13th arrondissement of Paris, 174 Avenue de France. The architecture of the head office is of the predominate style of the area surrounding the François Mitterrand Library. After Sanofi and Aventis merged, the employees at the former Aventis head office in Schiltigheim
Schiltigheim
Schiltigheim is a commune in the Bas-Rhin department in Alsace in north-eastern France.The inhabitants are called Schilikois in French and Scheligemer in Alsatian....

, Alsace
Alsace
Alsace is the fifth-smallest of the 27 regions of France in land area , and the smallest in metropolitan France. It is also the seventh-most densely populated region in France and third most densely populated region in metropolitan France, with ca. 220 inhabitants per km²...

 moved to Paris.

Collaborative research

In addition to internal research and development activities Sanofi is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical
Pre-clinical development
In drug development, pre-clinical development is a stage of research that begins before clinical trials can begin, and during which important feasibility, iterative testing and drug safety data is collected....

 safety assessment is the InnoMed PredTox. The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative
Innovative Medicines Initiative
The Innovative Medicines Initiative is a European initiative to improve the competitive situation of the European Union in the field of pharmaceutical research...

 of EFPIA and the European Commission
European Commission
The European Commission is the executive body of the European Union. The body is responsible for proposing legislation, implementing decisions, upholding the Union's treaties and the general day-to-day running of the Union....

.

In June 2010, Sanofi and the Charite University of Berlin
Berlin
Berlin is the capital city of Germany and is one of the 16 states of Germany. With a population of 3.45 million people, Berlin is Germany's largest city. It is the second most populous city proper and the seventh most populous urban area in the European Union...

 signed a cooperation agreement for the research and development of medicines and therapies.

Aventis Foundation

The Aventis Foundation, a German
Germany
Germany , officially the Federal Republic of Germany , is a federal parliamentary republic in Europe. The country consists of 16 states while the capital and largest city is Berlin. Germany covers an area of 357,021 km2 and has a largely temperate seasonal climate...

 charitable trust, was established in 1996 as the Hoechst Foundation with an endowment
Financial endowment
A financial endowment is a transfer of money or property donated to an institution. The total value of an institution's investments is often referred to as the institution's endowment and is typically organized as a public charity, private foundation, or trust....

 of €50 million. In 2000, the foundation was renamed the Aventis Foundation. Its aim is to promote music, theater, art, literature, higher education and healthcare research.

See also

  • sanofi-aventis international BioGENEius Challenge
    Sanofi-aventis international BioGENEius Challenge
    The sanofi-aventis International BioGENEius Challenge is a competition for high school students that recognizes original research in biotechnology. Held each year at the Biotechnology Industry Organization convention and organized by the Biotechnology Institute, it is considered the most...

  • Sanofi Pasteur
    Sanofi pasteur
    Sanofi Pasteur is the vaccines division of sanofi-aventis Group. It is the largest company in the world devoted entirely to vaccines.- History :...

The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
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