Bromodomain adjacent to zinc finger domain protein 1A is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the BAZ1A gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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Structure

The protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 encoded by this gene belongs to a family of proteins which includes BAZ1B

BAZ1B

Tyrosine-protein kinase BAZ1B is an enzyme that in humans is encoded by the BAZ1B gene.-Animal models:Model organisms have been used in the study of BAZ1B function...

, BAZ2A

BAZ2A

Bromodomain adjacent to zinc finger domain protein 2A is a protein that in humans is encoded by the BAZ2A gene.-Further reading:...

, and BAZ2B. All family members contain the following domains

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

 and structural motif

Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which appears also in a variety of other molecules...

s:

• N-terminus – PHD finger
  PHD finger
  The PHD finger was discovered in 1993 as a Cys4-His-Cys3 motif in the homeodomain protein HAT3 in Arabidopsis thaliana.The PHD finger motif resembles the metal binding RING domain and FYVE domain...
  
   (C4HC3 zinc finger
  Zinc finger
  Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...
  
  )
• WAKZ motif
• LH (leucine-rich
  Leucine-rich repeat
  A leucine-rich repeat is a protein structural motif that forms an α/β horseshoe fold. It is composed of repeating 20–30 amino acid stretches that are unusually rich in the hydrophobic amino acid leucine...
  
   helical domain) motif
• C-terminus – bromodomain
  Bromodomain
  A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha...
  
  

Function

BAZ1A along with SMARCA5

SMARCA5

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.-Interactions:...

, POLE3

POLE3

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.-Further reading:...

, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex

Chromatin Structure Remodeling (RSC) Complex

RSC is a 17-subunit complex with the capacity to remodel the structure of chromatin. It exhibits a DNA-dependent ATPase activity stimulated by both free and nucleosomal DNA and a capacity to perturb nucleosome structures...

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The purified CHRAC complex can mobilize nucleosome

Nucleosome

Nucleosomes are the basic unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound around a histone protein core. This structure is often compared to thread wrapped around a spool....

s into a regularly spaced nucleosomal array and the spacing activity is ATP-dependent. Furthermore the BAZ1A-SMARCA5 complex enables DNA replication

DNA replication

DNA replication is a biological process that occurs in all living organisms and copies their DNA; it is the basis for biological inheritance. The process starts with one double-stranded DNA molecule and produces two identical copies of the molecule...

 through highly condensed regions of chromatin

Chromatin

Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The primary functions of chromatin are; to package DNA into a smaller volume to fit in the cell, to strengthen the DNA to allow mitosis and meiosis and prevent DNA damage, and to control gene...

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Interactions

BAZ1A has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with SMARCA5

SMARCA5

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.-Interactions:...

 and SATB1

SATB1

SATB1 is a protein which in humans is encoded by the SATB1 gene.- Function :SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation...

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