Iron-sulfur world theory
Encyclopedia
The iron-sulfur world theory is a set of proposals for the origin of life and the early evolution of life advanced by Günter Wächtershäuser
, a Munich
patent lawyer with a degree in chemistry who had been encouraged and supported by philosopher Karl R. Popper to publish his ideas. The theory proposes that early life may have formed on the surface of iron sulfide
minerals, hence the name. It was developed by retrodiction from extant biochemistry in conjunction with chemical experiments.
and nickel
, but also perhaps cobalt
, manganese
, tungsten
and zinc
). The catalytic centers catalyzed autotrophic carbon fixation pathways generating small molecule (non-polymer) organic compounds from inorganic gases (e.g. carbon monoxide
, carbon dioxide
, hydrogen cyanide and hydrogen sulfide
). These organic compounds were retained on or in the mineral base as organic ligands of the transition metal centers with a flow retention time in correspondence with their mineral bonding strength thereby defining an autocatalytic "surface metabolism". The catalytic transition metal centers became autocatalytic by being accelerated by their organic products turned ligands. The carbon fixation metabolism became autocatalytic by forming a metabolic cycle in the form of a primitive sulfur-dependent version of the reductive citric acid cycle
. Accelerated catalysts expanded the metabolism and new metabolic products further accelerated the catalysts. The idea is that once such a primitive autocatalytic metabolism was established, its intrinsically synthetic chemistry began to produce ever more complex organic compounds, ever more complex pathways and ever more complex catalytic centers.
The fundamental idea of the origin of life according to the iron-sulfur world theory can be simplified in the following brief characterization: Pressurize and heat a water flow with dissolved volcanic gases (e.g. carbon monoxide
, ammonia
and hydrogen sulfide
) to 100°C. Pass the flow over catalytic transition metal solids (e.g. iron sulfide and nickel sulfide). Wait and locate the formation of catalytic metallo-peptides. Some crucial aspects of this theory have been confirmed experimentally.
(CO + H2O → CO2 + H2) occurs in volcanic fluids with diverse catalysts or without catalysts. The combination of ferrous sulfide and hydrogen sulfide as reducing agents in conjunction with pyrite formation – FeS + H2S → FeS2 + 2H+ + 2e- (or H2 instead of 2H+ + 2e-) – has been demonstrated under mild volcanic conditions. This key result has been disputed. Nitrogen fixation has been demonstrated for the isotope 15N2 in conjunction with pyrite formation. Ammonia forms from nitrate with FeS/H2S as reductant. Methylmercaptan [CH3-SH] and carbon oxysulfide [COS] form from CO2 and FeS/H2S, or from CO and H2 in the presence of NiS.
(CO) and hydrogen sulfide
(H2S) in the presence of nickel sulfide and iron sulfide
generates the methyl thioester
of acetic acid [CH3-CO-SCH3] and presumably thioacetic acid
(CH3-CO-SH) as the simplest activated acetic acid analogues of acetyl-CoA
. These activated acetic acid derivatives serve as starting materials for subsequent exergonic synthetic steps. They also serve for energy coupling with endergonic reactions, notably the formation of (phospho)anhydride compounds. Reaction of nickel hydroxide with hydrogen cyanide (HCN) (in the presence or absence of ferrous hydroxide, hydrogen sulfide
or methyl mercaptan) generates nickel cyanide, which reacts with carbon monoxide
(CO) to generate pairs of α-hydroxy and α-amino acids: e.g. glycolate/glycine
, lactate
/alanine
, glycerate/serine
; as well as pyruvic acid
in significant quantities. Pyruvic acid
is also formed at high pressure and high temperature from CO, H2O, FeS in the presence of nonyl mercaptan.
Reaction of pyruvic acid
or other α-keto acids with ammonia
in the presence of ferrous hydroxide or in the presence of ferrous sulfide and hydrogen sulfide
generates alanine or other α-amino acids. Reaction of α-amino acids in aqueous solution with COS or with CO and H2S generates a peptide cycle wherein dipeptides, tripeptide
s etc. are formed and subsequently degraded via N-terminal hydantoin
moieties and N-terminal urea
moieties and subsequent cleavage of the N-terminal amino acid unit.
). According to the iron-sulfur world theory it covers a coevolution of cellular organization (cellularization
), the genetic machinery and enzymatization of the metabolism
.
Kandler) because they allow frequent exchange of genetic material (e.g. by fusions). According to Woese, this frequent exchange of genetic material is the cause for the existence of the common stem in the tree of life and for a very rapid early evolution.
. These structures consist of microscale caverns that are coated by thin membraneous metal sulfide walls. Therefore, these structures would resolve several critical points germane to Wächtershäuser's suggestions at once:
This model locates the "last universal common ancestor" (LUCA
) within the inorganically formed physical confines of an alkaline hydrothermal vent, rather than assuming the existence of a free-living form of LUCA. The last evolutionary step en route to bona fide free-living cells would be the synthesis of a lipid membrane that finally allows the organisms to leave the microcavern system of the vent. This postulated late acquisition of the biosynthesis of lipids as directed by genetically encoded peptides is consistent with the presence of completely different types of membrane lipids in archaea
and bacteria
(plus eukaryotes). The kind of vent at the foreground of their suggestion is chemically more similar to the warm (ca. 100 °C) off ridge vents such as Lost City
than to the more familiar black smoker type vents (ca. 350 °C).
In an abiotic world, a thermocline
of temperatures and a chemocline
in concentration is associated with the pre-biotic synthesis of organic molecules, hotter in proximity to the chemically rich vent, cooler but also less chemically rich at greater distances. The migration of synthesized compounds from areas of high concentration to areas of low concentration gives a directionality that provides both source and sink in a self-organizing fashion, enabling a proto-metabolic process by which acetic acid
production and its eventual oxidization can be spatially organized.
In this way many of the individual reactions that are today found in central metabolism could initially have occurred independent of any developing cell membrane
. Each vent microcompartment is functionally equivalent to a single cell. Chemical communities having greater structural integrity and resilience to wildly fluctuating conditions are then selected for; their success would lead to local zones of depletion for important precursor chemicals. Progressive incorporation of these precursor components within a cell membrane would gradually increase metabolic complexity
within the cell membrane, whilst leading to greater environmental simplicity in the external environment. In principle, this could lead to the development of complex catalytic sets capable of self-maintenance
.
Russell adds a significant factor to these ideas, by pointing out that semi-permeable mackinawite
(an iron sulfide mineral) and silicate membranes could naturally develop under these conditions and electrochemically link reactions separated in space, if not in time.
Günter Wächtershäuser
Günter Wächtershäuser , a German chemist turned patent lawyer, is mainly known for his work on the origin of life, and in particular his iron-sulfur world theory, a theory that life on Earth had hydrothermal origins...
, a Munich
Munich
Munich The city's motto is "" . Before 2006, it was "Weltstadt mit Herz" . Its native name, , is derived from the Old High German Munichen, meaning "by the monks' place". The city's name derives from the monks of the Benedictine order who founded the city; hence the monk depicted on the city's coat...
patent lawyer with a degree in chemistry who had been encouraged and supported by philosopher Karl R. Popper to publish his ideas. The theory proposes that early life may have formed on the surface of iron sulfide
Iron sulfide
Iron sulfide or Iron sulphide refers to a chemical compound of iron and sulfur with a wide range of stoechiometric formulae and different crystalline structures.-Natural minerals:By increasing order of stability:...
minerals, hence the name. It was developed by retrodiction from extant biochemistry in conjunction with chemical experiments.
Pioneer organism
Wächtershäuser proposes that the earliest form of life, termed "pioneer organism", originated in a volcanic hydrothermal flow at high pressure and high (100°C) temperature. It had a composite structure of a mineral base with catalytic transition metal centers (predominantly ironIron
Iron is a chemical element with the symbol Fe and atomic number 26. It is a metal in the first transition series. It is the most common element forming the planet Earth as a whole, forming much of Earth's outer and inner core. It is the fourth most common element in the Earth's crust...
and nickel
Nickel
Nickel is a chemical element with the chemical symbol Ni and atomic number 28. It is a silvery-white lustrous metal with a slight golden tinge. Nickel belongs to the transition metals and is hard and ductile...
, but also perhaps cobalt
Cobalt
Cobalt is a chemical element with symbol Co and atomic number 27. It is found naturally only in chemically combined form. The free element, produced by reductive smelting, is a hard, lustrous, silver-gray metal....
, manganese
Manganese
Manganese is a chemical element, designated by the symbol Mn. It has the atomic number 25. It is found as a free element in nature , and in many minerals...
, tungsten
Tungsten
Tungsten , also known as wolfram , is a chemical element with the chemical symbol W and atomic number 74.A hard, rare metal under standard conditions when uncombined, tungsten is found naturally on Earth only in chemical compounds. It was identified as a new element in 1781, and first isolated as...
and zinc
Zinc
Zinc , or spelter , is a metallic chemical element; it has the symbol Zn and atomic number 30. It is the first element in group 12 of the periodic table. Zinc is, in some respects, chemically similar to magnesium, because its ion is of similar size and its only common oxidation state is +2...
). The catalytic centers catalyzed autotrophic carbon fixation pathways generating small molecule (non-polymer) organic compounds from inorganic gases (e.g. carbon monoxide
Carbon monoxide
Carbon monoxide , also called carbonous oxide, is a colorless, odorless, and tasteless gas that is slightly lighter than air. It is highly toxic to humans and animals in higher quantities, although it is also produced in normal animal metabolism in low quantities, and is thought to have some normal...
, carbon dioxide
Carbon dioxide
Carbon dioxide is a naturally occurring chemical compound composed of two oxygen atoms covalently bonded to a single carbon atom...
, hydrogen cyanide and hydrogen sulfide
Hydrogen sulfide
Hydrogen sulfide is the chemical compound with the formula . It is a colorless, very poisonous, flammable gas with the characteristic foul odor of expired eggs perceptible at concentrations as low as 0.00047 parts per million...
). These organic compounds were retained on or in the mineral base as organic ligands of the transition metal centers with a flow retention time in correspondence with their mineral bonding strength thereby defining an autocatalytic "surface metabolism". The catalytic transition metal centers became autocatalytic by being accelerated by their organic products turned ligands. The carbon fixation metabolism became autocatalytic by forming a metabolic cycle in the form of a primitive sulfur-dependent version of the reductive citric acid cycle
Citric acid cycle
The citric acid cycle — also known as the tricarboxylic acid cycle , the Krebs cycle, or the Szent-Györgyi-Krebs cycle — is a series of chemical reactions which is used by all aerobic living organisms to generate energy through the oxidization of acetate derived from carbohydrates, fats and...
. Accelerated catalysts expanded the metabolism and new metabolic products further accelerated the catalysts. The idea is that once such a primitive autocatalytic metabolism was established, its intrinsically synthetic chemistry began to produce ever more complex organic compounds, ever more complex pathways and ever more complex catalytic centers.
The fundamental idea of the origin of life according to the iron-sulfur world theory can be simplified in the following brief characterization: Pressurize and heat a water flow with dissolved volcanic gases (e.g. carbon monoxide
Carbon monoxide
Carbon monoxide , also called carbonous oxide, is a colorless, odorless, and tasteless gas that is slightly lighter than air. It is highly toxic to humans and animals in higher quantities, although it is also produced in normal animal metabolism in low quantities, and is thought to have some normal...
, ammonia
Ammonia
Ammonia is a compound of nitrogen and hydrogen with the formula . It is a colourless gas with a characteristic pungent odour. Ammonia contributes significantly to the nutritional needs of terrestrial organisms by serving as a precursor to food and fertilizers. Ammonia, either directly or...
and hydrogen sulfide
Hydrogen sulfide
Hydrogen sulfide is the chemical compound with the formula . It is a colorless, very poisonous, flammable gas with the characteristic foul odor of expired eggs perceptible at concentrations as low as 0.00047 parts per million...
) to 100°C. Pass the flow over catalytic transition metal solids (e.g. iron sulfide and nickel sulfide). Wait and locate the formation of catalytic metallo-peptides. Some crucial aspects of this theory have been confirmed experimentally.
Nutrient conversions
The water gas shift reactionWater gas shift reaction
The water-gas shift reaction is a chemical reaction in which carbon monoxide reacts with water vapor to form carbon dioxide and hydrogen:The water-gas shift reaction is an important industrial reaction. It is often used in conjunction with steam reforming of methane or other hydrocarbons, which is...
(CO + H2O → CO2 + H2) occurs in volcanic fluids with diverse catalysts or without catalysts. The combination of ferrous sulfide and hydrogen sulfide as reducing agents in conjunction with pyrite formation – FeS + H2S → FeS2 + 2H+ + 2e- (or H2 instead of 2H+ + 2e-) – has been demonstrated under mild volcanic conditions. This key result has been disputed. Nitrogen fixation has been demonstrated for the isotope 15N2 in conjunction with pyrite formation. Ammonia forms from nitrate with FeS/H2S as reductant. Methylmercaptan [CH3-SH] and carbon oxysulfide [COS] form from CO2 and FeS/H2S, or from CO and H2 in the presence of NiS.
Synthetic reactions
Reaction of carbon monoxideCarbon monoxide
Carbon monoxide , also called carbonous oxide, is a colorless, odorless, and tasteless gas that is slightly lighter than air. It is highly toxic to humans and animals in higher quantities, although it is also produced in normal animal metabolism in low quantities, and is thought to have some normal...
(CO) and hydrogen sulfide
Hydrogen sulfide
Hydrogen sulfide is the chemical compound with the formula . It is a colorless, very poisonous, flammable gas with the characteristic foul odor of expired eggs perceptible at concentrations as low as 0.00047 parts per million...
(H2S) in the presence of nickel sulfide and iron sulfide
Iron sulfide
Iron sulfide or Iron sulphide refers to a chemical compound of iron and sulfur with a wide range of stoechiometric formulae and different crystalline structures.-Natural minerals:By increasing order of stability:...
generates the methyl thioester
Thioester
Thioesters are compounds with the functional group C-S-CO-C. They are the product of esterification between a carboxylic acid and a thiol. Thioesters are widespread in biochemistry, the best-known derivative being acetyl-CoA.-Synthesis:...
of acetic acid [CH3-CO-SCH3] and presumably thioacetic acid
Thioacetic acid
Thioacetic acid is an organosulfur compound with the molecular formula CH3COSH. It is a colourless liquid with a strong thiol-like odor. It is used in organic synthesis for the introduction of thiol groups in molecules-Synthesis and properties:...
(CH3-CO-SH) as the simplest activated acetic acid analogues of acetyl-CoA
Acetyl-CoA
Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions. Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. In chemical structure, acetyl-CoA is the thioester...
. These activated acetic acid derivatives serve as starting materials for subsequent exergonic synthetic steps. They also serve for energy coupling with endergonic reactions, notably the formation of (phospho)anhydride compounds. Reaction of nickel hydroxide with hydrogen cyanide (HCN) (in the presence or absence of ferrous hydroxide, hydrogen sulfide
Hydrogen sulfide
Hydrogen sulfide is the chemical compound with the formula . It is a colorless, very poisonous, flammable gas with the characteristic foul odor of expired eggs perceptible at concentrations as low as 0.00047 parts per million...
or methyl mercaptan) generates nickel cyanide, which reacts with carbon monoxide
Carbon monoxide
Carbon monoxide , also called carbonous oxide, is a colorless, odorless, and tasteless gas that is slightly lighter than air. It is highly toxic to humans and animals in higher quantities, although it is also produced in normal animal metabolism in low quantities, and is thought to have some normal...
(CO) to generate pairs of α-hydroxy and α-amino acids: e.g. glycolate/glycine
Glycine
Glycine is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its 'side chain', glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG cf. the genetic code.Glycine is a colourless, sweet-tasting crystalline solid...
, lactate
Lactate
Lactate may refer to:*The act of lactation*The conjugate base of lactic acid...
/alanine
Alanine
Alanine is an α-amino acid with the chemical formula CH3CHCOOH. The L-isomer is one of the 20 amino acids encoded by the genetic code. Its codons are GCU, GCC, GCA, and GCG. It is classified as a nonpolar amino acid...
, glycerate/serine
Serine
Serine is an amino acid with the formula HO2CCHCH2OH. It is one of the proteinogenic amino acids. By virtue of the hydroxyl group, serine is classified as a polar amino acid.-Occurrence and biosynthesis:...
; as well as pyruvic acid
Pyruvic acid
Pyruvic acid is an organic acid, a ketone, as well as the simplest of the alpha-keto acids. The carboxylate ion of pyruvic acid, CH3COCOO−, is known as pyruvate, and is a key intersection in several metabolic pathways....
in significant quantities. Pyruvic acid
Pyruvic acid
Pyruvic acid is an organic acid, a ketone, as well as the simplest of the alpha-keto acids. The carboxylate ion of pyruvic acid, CH3COCOO−, is known as pyruvate, and is a key intersection in several metabolic pathways....
is also formed at high pressure and high temperature from CO, H2O, FeS in the presence of nonyl mercaptan.
Reaction of pyruvic acid
Pyruvic acid
Pyruvic acid is an organic acid, a ketone, as well as the simplest of the alpha-keto acids. The carboxylate ion of pyruvic acid, CH3COCOO−, is known as pyruvate, and is a key intersection in several metabolic pathways....
or other α-keto acids with ammonia
Ammonia
Ammonia is a compound of nitrogen and hydrogen with the formula . It is a colourless gas with a characteristic pungent odour. Ammonia contributes significantly to the nutritional needs of terrestrial organisms by serving as a precursor to food and fertilizers. Ammonia, either directly or...
in the presence of ferrous hydroxide or in the presence of ferrous sulfide and hydrogen sulfide
Hydrogen sulfide
Hydrogen sulfide is the chemical compound with the formula . It is a colorless, very poisonous, flammable gas with the characteristic foul odor of expired eggs perceptible at concentrations as low as 0.00047 parts per million...
generates alanine or other α-amino acids. Reaction of α-amino acids in aqueous solution with COS or with CO and H2S generates a peptide cycle wherein dipeptides, tripeptide
Tripeptide
A tripeptide is a peptide consisting of three amino acids joined by peptide bonds.Examples of tripeptides are:*Eisenin is a peptide with immunological activity that is isolated from the Japanese marine alga, Eisenia bicyclis, which more commonly is known as, Arame*GHK-Cu is a human copper binding...
s etc. are formed and subsequently degraded via N-terminal hydantoin
Hydantoin
Hydantoin, which is also known as glycolylurea, is a heterocyclic organic compound that can be thought of as a cyclic "double-condensation reaction" product of glycolic acid and urea...
moieties and N-terminal urea
Urea
Urea or carbamide is an organic compound with the chemical formula CO2. The molecule has two —NH2 groups joined by a carbonyl functional group....
moieties and subsequent cleavage of the N-terminal amino acid unit.
Early evolution
Early evolution is defined as beginning with the origin of life and ending with the last universal common ancestor (LUCALuca
Luca is Italian and Romanian for the name Luke.Luca or LUCA may refer to: the Last Universal Common Ancestor.*Luca is the greek word for legendary- People :* Luca , including a list of people with the given name Luca...
). According to the iron-sulfur world theory it covers a coevolution of cellular organization (cellularization
Cellularization
The theory of cellularization, also known as Ciliate-acoel theory, is one of the theories explaining the origin of the metazoans. It was first based on Ernst Haeckel's assumption that the earliest animals derived from ciliate protozoans. Haeckel later abandoned this idea which is revived by Hadzi...
), the genetic machinery and enzymatization of the metabolism
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
.
Cellularization
Cellularization occurs in several stages. It begins with the formation of primitive lipids (e.g. fatty acids or isoprenoid acids) in the surface metabolism. These lipids accumulate on or in the mineral base. This lipophilizes the outer or inner surfaces of the mineral base, which promotes condensation reactions over hydrolytic reactions by lowering the activity of water and protons. In the next stage lipid membranes are formed. While still anchored to the mineral base they form a semi-cell bounded partly by the mineral base and partly by the membrane. Further lipid evolution leads to self-supporting lipid membranes and closed cells. The earliest closed cells are pre-cells (sensuSensu
Sensu is a Latin word meaning "in the sense of".It is used in a number of fields including biology, geology, linguistics, and law. Commonly it refers to how strictly or loosely an expression is used, but it also appears in expressions that indicate the convention or context of the usage.-Sensu and...
Kandler) because they allow frequent exchange of genetic material (e.g. by fusions). According to Woese, this frequent exchange of genetic material is the cause for the existence of the common stem in the tree of life and for a very rapid early evolution.
Proto-ecological systems
William Martin and Michael Russell suggest that the first cellular life forms may have evolved inside alkaline hydrothermal vents at seafloor spreading zones in the deep seaDeep sea
The deep sea, or deep layer, is the lowest layer in the ocean, existing below the thermocline and above the seabed, at a depth of 1000 fathoms or more. Little or no light penetrates this part of the ocean and most of the organisms that live there rely for subsistence on falling organic matter...
. These structures consist of microscale caverns that are coated by thin membraneous metal sulfide walls. Therefore, these structures would resolve several critical points germane to Wächtershäuser's suggestions at once:
- the micro-caverns provide a means of concentrating newly synthesised molecules, thereby increasing the chance of forming oligomerOligomerIn chemistry, an oligomer is a molecule that consists of a few monomer units , in contrast to a polymer that, at least in principle, consists of an unlimited number of monomers. Dimers, trimers, and tetramers are oligomers. Many oils are oligomeric, such as liquid paraffin...
s; - the steep temperature gradients inside the hydrothermal vent allow for establishing "optimum zones" of partial reactions in different regions of the vent (e.g. monomer synthesis in the hotter, oligomerisation in the colder parts);
- the flow of hydrothermal water through the structure provides a constant source of building blocks and energy (chemical disequilibrium between hydrothermal hydrogen and marine carbon dioxide);
- the model allows for a succession of different steps of cellular evolution (prebiotic chemistry, monomer and oligomer synthesis, peptide and protein synthesis, RNA world, ribonucleoprotein assembly and DNADNADeoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
world) in a single structure, facilitating exchange between all developmental stages; - synthesis of lipids as a means of "closing" the cells against the environment is not necessary, until basically all cellular functions are developed.
This model locates the "last universal common ancestor" (LUCA
Luca
Luca is Italian and Romanian for the name Luke.Luca or LUCA may refer to: the Last Universal Common Ancestor.*Luca is the greek word for legendary- People :* Luca , including a list of people with the given name Luca...
) within the inorganically formed physical confines of an alkaline hydrothermal vent, rather than assuming the existence of a free-living form of LUCA. The last evolutionary step en route to bona fide free-living cells would be the synthesis of a lipid membrane that finally allows the organisms to leave the microcavern system of the vent. This postulated late acquisition of the biosynthesis of lipids as directed by genetically encoded peptides is consistent with the presence of completely different types of membrane lipids in archaea
Archaea
The Archaea are a group of single-celled microorganisms. A single individual or species from this domain is called an archaeon...
and bacteria
Bacteria
Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...
(plus eukaryotes). The kind of vent at the foreground of their suggestion is chemically more similar to the warm (ca. 100 °C) off ridge vents such as Lost City
Lost City (hydrothermal field)
Lost City is a field of hydrothermal vents in the mid-Atlantic ocean that differ significantly from the black smoker vents found in the late 1970s. The vents were discovered in December 2000 during a National Science Foundation expedition to the mid-Atlantic. A second expedition mounted in 2003...
than to the more familiar black smoker type vents (ca. 350 °C).
In an abiotic world, a thermocline
Thermocline
A thermocline is a thin but distinct layer in a large body of fluid , in which temperature changes more rapidly with depth than it does in the layers above or below...
of temperatures and a chemocline
Chemocline
A chemocline is a cline caused by a strong, vertical chemistry gradient within a body of water. A chemocline is analogous to a thermocline, the border at which warmer and cooler waters meet in an ocean, sea, lake, or other body of water...
in concentration is associated with the pre-biotic synthesis of organic molecules, hotter in proximity to the chemically rich vent, cooler but also less chemically rich at greater distances. The migration of synthesized compounds from areas of high concentration to areas of low concentration gives a directionality that provides both source and sink in a self-organizing fashion, enabling a proto-metabolic process by which acetic acid
Acetic acid
Acetic acid is an organic compound with the chemical formula CH3CO2H . It is a colourless liquid that when undiluted is also called glacial acetic acid. Acetic acid is the main component of vinegar , and has a distinctive sour taste and pungent smell...
production and its eventual oxidization can be spatially organized.
In this way many of the individual reactions that are today found in central metabolism could initially have occurred independent of any developing cell membrane
Cell membrane
The cell membrane or plasma membrane is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. It basically protects the cell...
. Each vent microcompartment is functionally equivalent to a single cell. Chemical communities having greater structural integrity and resilience to wildly fluctuating conditions are then selected for; their success would lead to local zones of depletion for important precursor chemicals. Progressive incorporation of these precursor components within a cell membrane would gradually increase metabolic complexity
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
within the cell membrane, whilst leading to greater environmental simplicity in the external environment. In principle, this could lead to the development of complex catalytic sets capable of self-maintenance
Autocatalytic set
An autocatalytic set is a collection of entities, each of which can be created catalytically by other entities within the set, such that as a whole, the set is able to catalyze its own production. In this way the set as a whole is said to be autocatalytic...
.
Russell adds a significant factor to these ideas, by pointing out that semi-permeable mackinawite
Mackinawite
Mackinawite is an iron nickel sulfide mineral with formula 1 + xS . It crystallizes in the tetragonal crystal system and occurs as opaque bronze to grey-white tabular crystals and anhedral masses. It has a Mohs hardness of 2.5 and a specific gravity of 4.17.-Occurrence:It occurs in serpentinized...
(an iron sulfide mineral) and silicate membranes could naturally develop under these conditions and electrochemically link reactions separated in space, if not in time.